18F-flortaucipir tau PET combined with APOE ε4 genotype for diagnosing mild cognitive impairment
10.13929/j.issn.1003-3289.2025.02.003
- VernacularTitle:18F-flortaucipir tau PET联合APOE ε4基因诊断轻度认知障碍
- Author:
Shaozhen YAN
1
;
Zhigeng CHEN
;
Sheng BI
;
Yujie HE
;
Hanxiao XUE
;
Xiaoyin XU
;
Zhigang QI
;
Yong LIU
;
Jie LU
Author Information
1. 首都医科大学宣武医院放射与核医学科,北京 100053;磁共振成像脑信息学北京市重点实验室,北京 100053;教育部神经变性病重点实验室,北京 100053
- Publication Type:Journal Article
- Keywords:
cognition disorders;
Alzheimer disease;
positron-emission tomography;
tau proteins;
apolipoprotein E epsilon 4
- From:
Chinese Journal of Medical Imaging Technology
2025;41(2):191-195
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of 18F-flortaucipir tau PET combined with APOE ε4 genotype status for diagnosing mild cognitive impairment(MCI).Methods A total of 213 MCI patients(MCI group)and 402 healthy controls(HC group)were selected from Alzheimer's disease neuroimaging initiative(ADNI)database.The neuropsychological information,APOE ε4 gene carrier status,tau PET and high-resolution structural MRI data were recorded.The random forest algorithm was used to screen the most informative brain regions of tau PET for diagnosing MCI,and the efficacy of tau PET for distinguishing MCI with or without APOE ε4 gene and HC were compared.Results Amygdala,parahippocampal gyrus,entorhinal cortex,posterior cingulate gyrus,inferior temporal gyrus,fusiform gyrus and middle temporal gyrus in turn were the important brain regions of tau PET for diagnosing MCI.The accuracy and the area under the curve(AUC)of tau PET standardized uptake value ratio(SUVR)model for identifying MCI with APOE ε4 gene and HC was 86.68％and 0.784,respectively,both higher than those for identifying MCI and HC,as well as MCI without APOE e4 gene and HC(with accuracy of 70.57％and 75.05％,and AUC of 0.711 and 0.609).Conclusion 18F-flortaucipir tau PET SUVR model established based on amygdala,parahippocampal gyrus,entorhinal cortex,posterior cingulate gyrus,inferior temporal gyrus,fusiform gyrus and middle temporal gyrus could be used to diagnosing MCI.Combining with APOE ε4 gene could further improve its efficacy.
