1 new case of hepatitis B-induced acute liver failure after receiving heart transplantation from a HBV-positive donor and literature review
10.11816/cn.ni.2025-241097
- VernacularTitle:HBV阳性供者心脏移植术后新发乙型肝炎致急性肝衰竭1例及文献回顾
- Author:
Ding ZHU
1
;
Kai GUO
;
Yong ZHANG
;
Hengning KE
Author Information
1. 武汉大学中南医院感染科,湖北省艾滋病临床指导培训中心,湖北武汉 430071
- Publication Type:Journal Article
- Keywords:
Heart transplantation;
Hepatitis B virus;
Antiviral therapy;
Acute hepatic failure
- From:
Chinese Journal of Nosocomiology
2025;35(6):875-878
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To summarize the follow-up,survival time and treatment of a patients who received heart transplantation from a hepatitis B virus(HBV)-positive donor so as to raise the perception and awareness of pre-vention of hepatitis B after receiving the heart transplantation from a HBV-positive donor and extend the survival time of the patient.METHODS A patient who had new onset of hepatitis B after receiving heart transplantation from a HBV-positive donor and was treated in infectious diseases department of Zhongnan Hospital of Wuhan Uni-versity in Mar.2021 was enrolled in the study.The clinical data,including the main clinical symptoms,medication and treatment history,individual history,major positive signs and treatment outcomes,were retrospectively ana-lyzed.The process of diagnosis and treatment was analyzed and was further discussed in combination with litera-ture search.RESULTS The patient was treated with immunosuppression and anti-HBV therapy for 11 months after the heart transplantation,and the patient had anorexia,fatigue,diarrhea,and skin icteric sclera in the current month of withdrawal of drug therapy.The patient was admitted to the hospital and was finally diagnosed with a-cute hepatic failure,acute hepatitis B,acute renal failure,septic shock,heart transplantation and gastrointestinal hemorrhage.The patient died due to ineffective treatment.CONCLUSIONS The patient with new onset of HBV in-fection who receives organ transplantation and takes a long-term use of immunosuppressors may have severe con-sequences such as new onset of hepatitis B and acute hepatic failure.It is necessary to attach great importance to and take comprehensive measures for the prevention of new onset HBV infection in the donor after the organ transplantation,stick to the long-term reexamination of HBV infection-related indexes and maintain the antiviral therapy as long as possible(at least 1 year),which may facilitate the protection of the patient from HBV infec-tion-related adverse events and help to extend the survival time of the patient after the organ transplantation.
