The effectiveness of the peripheral arterial calcification scoring system based on CT angiography in assessing renal function in patients with peripheral arterial disease
10.3969/j.issn.1002-1671.2025.04.011
- VernacularTitle:基于CT血管成像的外周动脉钙化评分系统在评估外周动脉疾病患者肾功能中应用价值
- Author:
Yuling CUI
1
;
Ningning DING
;
Li ZHOU
;
Yan MENG
;
Yaqing HAN
;
Cuilin YIN
;
Zhe LIU
;
Jian YANG
Author Information
1. 西安交通大学第一附属医院医学影像科,陕西 西安 710061
- Publication Type:Journal Article
- Keywords:
peripheral arterial calcification scoring system;
peripheral arterial disease;
calcification;
computed tomography angiography
- From:
Journal of Practical Radiology
2025;41(4):589-593
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effectiveness of the peripheral arterial calcification scoring system(PACSS)based on computed tomography angiography(CTA)in assessing renal function in patients with peripheral arterial disease(PAD).Methods The clinical data,CTA imaging data,and laboratory results from PAD patients who underwent lower limb artery CTA examination were retrospectively collected.The PACSS was utilized to score the calcification in both lower limb arteries.Participants were categorized into three groups based on their estimated glomerular filtration rate(eGFR)(normal group:eGFR≥90 mL/min;mild renal dysfunction group:eGFR 60-89 mL/min,and moderate to severe renal dysfunction group:eGFR＜60 mL/min).The demographic data,clinical symptoms,and comorbidities among the three groups were compared by analysis of variance(ANOVA).The Spearman correlation coefficient was employed to evaluate the relationship between eGFR,cystatin C,and PACSS score.Results The age(P＜0.001)and PACSS score(P＜0.05)of patients with renal dysfunction were significantly higher than those of patients with normal renal function.However,there were no significant differences in gender,prevalence of diabetes,hypertension,or severe limb ischemia.Spearman correlation analysis showed that eGFR was negatively correlated with PACSS score(r=-0.18 in the right lower limb,P=0.037,r=-0.24 in the left lower limb,P=0.006).In contrast,cystatin C was positively correlated with PACSS score(r=0.26 in the right lower limb,P＜0.001,r=0.22 in the left lower limb,P=0.002).Conclusion The PACSS score of lower limb artery in PAD patients is corre-lated with the severity of renal dysfunction.This finding may facilitate early warning and clinical intervention for PAD patients with renal dysfunction.
