The relationship between serum 25 hydroxyvitamin D levels and insulin resistance
10.3969/j.issn.1673-9701.2025.03.003
- VernacularTitle:血清25-羟维生素D水平与胰岛素抵抗的关系
- Author:
Xiaoli WANG
1
;
Fachang YU
;
Hongwei MA
;
Yuanfang WANG
;
Hua XU
Author Information
1. 济南市第五人民医院内分泌科,山东济南 250031
- Publication Type:Journal Article
- Keywords:
25-hydroxyvitamin D;
Insulin resistance;
HOMA-IR;
HOMA-β;
Thyroglobulin antibodies;
Diabetes mellitus
- From:
China Modern Doctor
2025;63(3):9-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between 25-hydroxyvitamin D[25(OH)D]and insulin resistance.Methods A total of 112 diabetic patients hospitalized in Department of Endocrinology,the Fifth People's Hospital of Jinan from June 2021 to December 2022 were selected as observation group by using random number table method,and 61 individuals in endocrinology clinic with normal blood glucose levels were selected as control group.The levels of 25(OH)D,blood glucose level,homeostasis model assessment of insulin resistance(HOMA-IR),homeostasis model assessment of β-cell function(HOMA-β),thyroglobulin antibodies,and diabetes-related antibodies[insulin autoantibodies(IAA),islet cell antibody(ICA)and glutamic acid decarboxylase antibody(GAD)]etc indexs were measured in two groups,and the correlation between 25(OH)D and blood glucose,thyroglobulin antibody,diabetes-related antibody and pancreatic function was analyzed.Results The level of 25(OH)D in observation group was significantly lower than that in control group,and the difference was statistically significant(P＜0.05).Correlation analysis showed that the level of 25(OH)D was negatively correlated with thyroglobulin antibodies,glycosylated hemoglobin,IAA,GAD,ICA,and HOMA-IR etc(P＜0.01)in all subjects,and positively correlated with gender and HOMA-β(P＜0.01).In observation group,the level of 25(OH)D was negatively correlated with HOMA-IR(P＜0.01)and positively correlated with HOMA-β(P＜0.01).Conclusion Insulin resistance and immune damage may be related to insufficient the level of serum 25(OH)D.It is suggested that individuals with diabetes and those at high risk of diabetes should supplement with vitamin D appropriately in the early stage.
