The cerebro protective effect of sivelestat sodium in cardiopulmonary bypass surgery
10.3969/j.issn.1673-9701.2025.03.013
- VernacularTitle:体外循环手术中西维来司他钠的脑保护作用
- Author:
Zhi WEN
1
;
Ou LIAO
;
Jian WEN
;
Feng REN
;
Zheng WANG
;
Changxue WU
Author Information
1. 德阳市人民医院心胸血管外科,四川德阳 618000
- Publication Type:Journal Article
- Keywords:
Sivelestat sodium;
S-100 protein;
IL-6;
Cerebro protection;
Cardiopulmonary bypass
- From:
China Modern Doctor
2025;63(3):53-56,72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cerebro protective effect of pre-filled sivelestat sodium during cardiopulmonary bypass(CPB)in patients with valve replacement surgery.Methods From January 2022 to December 2023,104 patients were included and randomly divided into experimental group(n=54)and control group(n=50).The sivelestat sodium 4.8mg/kg was mixed to the pre-filled solutions for CPB in experimental group,while an equal amount of physiological saline solution was mixed in control group.Internal jugular venous blood was collected 5 minutes after anesthesia induction and 10 minutes,4 hours,24 hours,and 72 hours after the aortic cross-clamp was released to detect plasma S-100 protein and interleukin(IL)-6 concentrations.Data on operation time,CPB time,mean arterial pressure,and hematocrit were also recorded.Results There were no statistical differences in operation time,CPB time,assisted circulation time,mean arterial pressure,and hematocrit between two groups(P＞0.05).After anesthesia,there were no significant differences in S-100 protein and IL-6 between two groups(P＞0.05).After,the plasma concentrations of S-100 protein and IL-6 increased in both groups,but the concentrations of S-100 protein and IL-6 in experimental group were significantly lower than those in control group at early stages(10 minutes,4 hours,24 hours)after the aortic cross-clamp was released(P＜0.05).Conclusion Sivelestat sodium,as a cerebro protective drug in CPB heart surgery,can reduce the levels of S-100 protein and IL-6,demonstrating a protective effect on central nervous cells.
