Research on expression significance and oncogenic mechanism of UGP2 in breast cancer
10.3969/j.issn.1009-9905.2025.03.006
- VernacularTitle:UGP2在乳腺癌中的表达意义及其促癌机制
- Author:
Zi-lin ZHENG
1
;
Xiao-jun ZHANG
;
Jian-jun HAN
;
Xin-yi LIANG
;
Xuan-chi GUO
;
Xiang-hui MEI
;
Jian-chao HE
Author Information
1. 河北工程大学 临床医学院(河北 邯郸 056000)
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
UGP2;
Bioinformatics;
Immune infiltration;
Prognosis
- From:
Chinese Journal of Current Advances in General Surgery
2025;28(3):196-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to investigate the expression of uridine diphosphate-glucose[]pyrophos-phorylase 2(UGP2)in breast cancer(BC)tissues and its oncogenic mechanism,assessing its potential value as a diag-nostic and prognostic biomarker for breast cancer.Methods:(1)Online database analysis was conducted to assess UGP2 mRNA and protein expression levels in breast cancer and explore their correlation with clinical characteristics.Im-munohistochemistry(IHC)was used to verify UGP2 expression in human breast cancer tumor tissues and evaluate its relationship with clinicopathological features.(2)Kaplan-Meier survival analysis and COX regression models were used to analyze the impact of UGP2 expression on breast cancer patient prognosis.(3)Bioinformatics methods were em-ployed to investigate the correlation between UGP2 and tumor immune cell infiltration,and to predict the biological func-tions and associated signaling pathways of UGP2 in breast cancer.Results:(1)The mRNA and protein expression levels of UGP2 were upregulated in breast cancer tissues(both P<0.05),and were negatively correlated with ER-positive and PR-positive status(OR<1,P<0.05),while positively correlated with Ki-67 levels and the triple-negative breast cancer(TNBC)subtype(OR>1,P<0.05).(2)Elevated expression levels of UGP2 were associated with poorer survival rates in breast cancer patients(both P<0.05)and were identified as an independent adverse prognostic factor for breast cancer(HR=1.40,P<0.05).(3)Functional analysis results suggested that UGP2 may promote tumor progression by regulating metabolism,hormone signaling,and the immune microenvironment.Additionally,UGP2 expression was negatively cor-related with NK cell activation status and positively correlated with the inhibitory state.Conclusion:UGP2 expression is elevated in breast cancer tissues and is closely associated with poor patient prognosis.It may promote cancer pro-gression through mechanisms such as metabolic reprogramming and immune suppression.UGP2 shows promise as a potential biomarker and therapeutic target in breast cancer,providing a basis for personalized treatment.
