Progress in the Diagnosis and Treatment of Steroid-Unrespon-sive Pneumonitis Related to Immune Checkpoint Inhibitors
10.11735/j.issn.1004-0242.2025.03.A012
- VernacularTitle:激素无效性免疫检查点抑制剂相关肺炎的诊疗进展
- Author:
Xiangran FENG
1
;
Yongfeng GAO
;
Xiaofei LAN
;
Xianwen SUN
;
Jun ZHOU
;
Jingya ZHAO
;
Zhiyao BAO
;
Yi XIANG
Author Information
1. 上海交通大学医学院附属瑞金医院,上海 200025;上海交通大学医学院呼吸病研究所,上海 200025
- Publication Type:Journal Article
- Keywords:
immune checkpoint inhibitor-related pneumonitis;
glucocorticoids;
immunosuppressant;
anti-fibrotic therapy;
immune re-challenge
- From:
China Cancer
2025;34(3):244-250
- CountryChina
- Language:Chinese
-
Abstract:
Immune checkpoint inhibitor-related pneumonitis(CIP)is a relatively common immune-related adverse event.The current treatment for CIP mainly relies on glucocorticoids,with 70％～80％of patients being controlled by conventional glucocorticoid therapy.However,steroid-unresponsive CIP is often se-vere and can be life-threatening.There is no standard treatment protocol for steroid-unresponsive CIP,highlighting a significant unmet clinical need.This paper reviews the diagnosis,treatment progress,and exploratory research of steroid-unresponsive CIP to provide evidence-based guidelines and directions for clinical and translational research.
