The relationship between the serum uric acid to high density lipoprotein-cholesterol ratio and female infertility
10.3969/j.issn.1006-7795.2025.02.022
- VernacularTitle:血清尿酸与高密度脂蛋白胆固醇比值与女性不孕的关系
- Author:
Huanling JIAN
1
;
Zi DAI
;
Xiaoli CEN
;
Huiling CHEN
;
Zhiwen LIU
;
Ying ZHAO
Author Information
1. 广州中医药大学第一临床医学院一妇科,广州 510405;广州中医药大学第三附属医院教育科研部,广州 510378
- Publication Type:Journal Article
- Keywords:
serum uric acid;
high density lipoprotein-cholesterol;
uric acid to high density lipoprotein-cholesterol ratio;
infertility;
NHANES;
forecast;
biomarker
- From:
Journal of Capital Medical University
2025;46(2):348-355
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct a cross-sectional study on the relationship between the serum uric acid(sUA)to high density lipoprotein-cholesterol(HDL-C)ratio(UHR)and female infertility.Methods We analyzed data from the National Health and Nutrition Examination Survey(NHANES)2013-2018 cycle,examining 2,963 women aged 18 to 45 years.A multivariable Logistic regression model was used to assess the association between UHR and infertility,adjusting for various confounding factors.The study also explored interactions and dose-response relationships through subgroup analyses and restricted cubic spline(RCS)models,and evaluated the predictive value of UHR for infertility by using receiver operating characteristic(ROC)curve analysis.Results The results showed that the prevalence of infertility was significantly higher among women with elevated UHR.Baseline characteristics revealed that the mean UHR in women with infertility(9.68±4.23)was significantly higher than in those without infertility(8.7±3.81,P<0.001).Multivariable Logistic regression analysis indicated that women in the highest quartile(Q4)of UHR had a significantly increased likelihood of infertility compared to those in the lowest quartile(Q1),with adjusted odds ratios(ORs)ranging from 1.61(95% CI:1.14-2.28)to 1.98(95% CI:1.42-2.78)across different models(P for trend<0.001).Subgroup analyses demonstrated that these associations were consistent across different age groups,body mass index(BMI)categories,and racial groups.The RCS model showed a significant linear dose-response relationship between UHR and infertility risk(nonlinear P=0.03,overall association P<0.001).Additionally,ROC analysis indicated that UHR had a moderate ability to discriminate infertility status,with an area under the curve(AUC)of 0.570.Conclusion A higher UHR is significantly associated with an increased risk of female infertility,and UHR has the potential to serve as a predictive biomarker for the risk of female infertility.
