Regulation of unilateral stimulating striatal D1-MSN with different frequencies on movement in mice
10.3969/j.issn.1006-7795.2025.02.014
- VernacularTitle:不同频率单侧刺激小鼠背侧纹状体D1-MSN对小鼠运动速度的影响
- Author:
Fangyuan CHENG
1
;
Dongkun CHEN
1
;
Huijin LIU
1
;
Jun JIA
1
;
Ke WANG
1
Author Information
1. 首都医科大学基础医学院生理学与病理生理学系,北京 100069
- Publication Type:Journal Article
- Keywords:
basal ganglia loops;
striatum;
medium spiny neurons;
rotational behavior;
velocity;
mouse
- From:
Journal of Capital Medical University
2025;46(2):283-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the effect of unilateral activation of the dopamine type I receptor medium-sized multi-spiny neurons(D1-MSN)in the dorsal striatum of mice on speed.Methods The transgenic animals were combined with optogenetic experiments to specifically activate the D1-MSN in the dorsal striatum of mice at different frequencies and to analyze the rotational behavior and speed of mice when stimulating the D1-MSN.Results Unilateral activation of D1-MSN induces contralateral rotational behavior in mice and either increases or decreases speed.The mechanisms by which different frequencies affect the speed of mice differently.As the frequency of stimulus increased,the contralateral rotational behavior of the mice increased.Unilateral stimulus of D1-MSN increased speed and induced contralateral rotational behavior,and the rotational behavior increased with increasing stimulus frequency.In the experiment where D1-MSN stimulus did not induce rotational behavior,it was found that 5 Hz stimulus still induced an increase in speed,but 15 Hz and 25 Hz stimulus did not induce an increase in speed.Further analysis of the pre-stimulus locomotor state of the mice showed that 5 Hz,15 Hz and 25 Hz stimulus increased speed when the average speed before stimulus was less than 5 cm/s.However,15 Hz stimulus decreased the speed when the average speed before stimulus was greater than 5 cm/s.Conclusion Unilateral activation of D1-MSN in the dorsal striatum modulates speed and induces contralateral rotational behavior in mice,and is related to the frequency of stimulus and the locomotor state of the mice before stimulus.
