Titer study of hypocalcemia in early identification of sepsis-induced coagulopathy
10.3969/j.issn.1673-9701.2025.12.008
- VernacularTitle:低钙血症在脓毒症性凝血病早期诊断中的效价研究
- Author:
Chen LI
1
;
Aixiang YANG
1
;
Jun LIU
1
Author Information
1. 南京医科大学附属苏州医院重症医学科,江苏苏州 215001
- Publication Type:Journal Article
- Keywords:
Sepsis;
Sepsis-induced coagulopathy;
Hypocalcemia
- From:
China Modern Doctor
2025;63(12):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of hypocalcemia in early diagnosis of sepsis-induced coagulopathy(SIC).Methods Clinical data of 76 patients with sepsis in Department of Critical Care Medicine,the Affiliated Suzhou Hospital of Nanjing Medical University from April 2023 to April 2024 were retrospectively analyzed,patients were divided into SIC group(n=36)and non-SIC group(n=40),including age,sex,site of infection,underlying disease,sepsis-related organ failure assessment(SOFA)were collected.Arterial blood gas analysis,venous blood biochemistry,fibrinogen,inflammatory indicators procalcitonin(PCT),C-reactive protein(CRP),length of stay in Department of Critical Care Medicine,and mechanical ventilation time.Multivariate Logistic regression analysis and receiver operating characteristic(ROC)curve were used to evaluate the predictive value of serum calcium level in SIC.Results The age of patients in SIC group was significantly higher than that of non-SIC group(P＜0.05).The level of ionic calcium in SIC group was significantly lower than that in non-SIC group(P＜0.05).Inflammatory indicators PCT and CRP in SIC group were significantly higher than those in non-SIC group(P＜0.01).Multivariate logistic regression analysis showed that hypocalcemia was an independent risk factor for SIC(OR=3.431,95％CI:1.032-11.409).The area under ROC curve of the correlation between ionic calcium and SIC was 0.665(95％CI:0.543-0.788),and the best cut-off value was 1.03mmol/L.Conclusion Hypocalcemia is an independent risk factor for SIC.Active correction of early hypocalcemia is helpful to improve the clinical prognosis with SIC.
