Research progress on mechanism of action of Chaenomeles speciosa Nakai in the treatment of rheumatoid arthritis bone restruction
10.12092/j.issn.1009-2501.2025.03.014
- VernacularTitle:皱皮木瓜治疗类风湿性关节炎骨破坏作用机制研究进展
- Author:
Jun CAO
1
;
Yanlin ZHOU
;
Zhengwen AI
;
Shigang LI
Author Information
1. 三峡大学基础医学院,宜昌 443002,湖北;三峡大学健康医学院,宜昌 443002,湖北;三峡大学国家中医药管理局中药药理科研三级实验室,宜昌 443002,湖北
- Publication Type:Journal Article
- Keywords:
chaenomeles speciosa Nakai;
osteo-clast;
bone destruction;
rheumatoid arthritis;
mech-anism of action
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(3):404-411
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis is an autoim-mune disease characterized by progressive bone destruction,with joint swelling caused by synovial inflammation in the early stage,and joint deformi-ty caused by cartilage and bone destruction occur-ring in the middle and late stages as inflammation develops,resulting in a 75％disability and deformi-ty rate within three years,and the prevention and treatment of RA bone and joint destruction is of ur-gency,and it is therefore of great significance to search for effective drugs to treat RA bone destruc-tion.Studies have shown that wrinkled skin papaya can treat RA bone destruction,but the composition and mechanism of action are unknown,so this re-view aims to provide an overview of the mecha-nism of action of the effective active ingredients in wrinkled skin papaya for the treatment of rheuma-toid arthritis bone destruction,and to provide a ba-sis and direction for the development of novel for-mulations of traditional Chinese medicines for anti-RA bone destruction.
