Meta analysis of risk factors for spontaneous bacterial peritonitis in cirrhosis patients with ascites
10.11816/cn.ni.2025-241021
- VernacularTitle:肝硬化腹水并发自发性细菌性腹膜炎危险因素的Meta分析
- Author:
Xiaohui HAO
1
;
Lufei XING
;
Lihua WANG
;
Wenwen LIAN
Author Information
1. 解放军总医院第五医学中心南院区药剂科,北京 100071
- Publication Type:Journal Article
- Keywords:
Spontaneous bacterial peritonitis;
Liver cirrhosis;
Ascites;
Risk factor;
Meta analysis
- From:
Chinese Journal of Nosocomiology
2025;35(6):867-874
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To systematically evaluate the risk factors for spontaneous bacterial peritonitis(SBP)in the cirrhosis patients with ascites so as to provide bases for reducing the incidence of SBP.METHODS The literatures regarding to cirrhosis ascites complicated with SBP were retrieved from the databases such as PubMed,Embase,Cochrane Library,CBM,CNKI,Wanfang and VIP.The time frame of retrieval was limited from the establish-ment of the databases to Jan.10,2024.The quality of the literatures was evaluated by Newcastle-Ottawa Scale(NOS).The data were analyzed by using STATA 16.0.RESULTS A total of 43 pieces of literatures were included in the study,involving 9877 research subjects,3384 of whom were complicated with SBP.The result of meta a-nalysis showed that the risk factors(P＜0.05)for SBP in the cirrhosis patients with ascites included the general factor(history of SBP),the disease factors(gastrointestinal hemorrhage,diarrhea,diabetes mellitus),drug fac-tors(use of proton pump inhibitors),physiological indexes[low blood sodium,low serum albumin,high serum bilirubin,rise of C-reactive protein(CRP)],liver function scoring indexes[Child-turcotte-pugh(CTP)grade C,model of end-stage liver disease(MELD)],and ascites indexes[low ascites albumin,rise of ascites white blood cells and rise of tumor necrosis factor-α(TNF-α)].CONCLUSIONS SBP is one of the most severe complications in the cirrhosis patients with ascites.Multiple risk factors may have remarkable influence on the occurrence and de-velopment of SBP.It is necessary to take targeted interventions to the controllable risk factors during the clinical practice so as to effectively reduce the risk of SBP in the cirrhosis patients with ascites.
