Transition of body mass index and metabolic syndrome in patients with major depressive disorder
10.3969/j.issn.1006-7795.2025.02.005
- VernacularTitle:抑郁症患者体质量指数和代谢综合征转移规律研究
- Author:
Han QI
1
;
Chengcheng DONG
;
Rui LIU
;
Xuequan ZHU
;
Xuzhou LIN
;
Yanshu QIN
;
Zibo YU
;
Haining WANG
;
Lei LI
;
Yuan FENG
;
Ling ZHANG
;
Fang YAN
Author Information
1. 首都医科大学附属北京安定医院 国家精神疾病医学中心 国家精神心理疾病临床医学研究中心 精神疾病诊断与治疗北京市重点实验室,北京 100088;首都医科大学人脑保护高精尖创新中心,北京 100069
- Publication Type:Journal Article
- Keywords:
major depressive disorder;
metabolic syndrome;
body mass index;
overweight;
multi-state Markov model;
transition rules
- From:
Journal of Capital Medical University
2025;46(2):202-209
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the transition rules of normal body mass index(BMI),overweight and metabolic syndrome(MetS)in patients with major depressive disorder(MDD).Methods Patients with MDD who had multiple admission records between Jan 2016 and Nov 2021 in Beijing Anding Hospital,Capital Medical University were included.Based on the overweight and metabolic syndrome status assessed at each admission,the patients were categorized into three states:normal BMI,overweight and metabolic syndrome.A multi-state Markov model was used to analyze the transition intensity and transition frequency between three states and the influence of covariates on transitions.Results A total of 892 records of 398 subjects were included,with a median age of 56 years old and 31.4% males.The median follow-up period was 40 months.The multi-state model showed that there were 494 transitions between the three states,of which 5.1% moved from normal BMI to overweight and 5.5% moved from overweight to MetS.The intensity of transition was the highest from overweight to MetS,9.52 times greater than overweight to normal BMI.After 48.53 months,MDD patients with normal BMI began to transition to MetS.For overweight MDD patients,the transition to MetS started after 8.77 months.MDD patients with normal BMI or overweight had 31.4% and 50.4% probabilities of developing Mets after 36 months.For MDD patients comorbid with MetS,the probability of staying at MetS was 51.2% after 36 months.Multivariate analysis showed that being unmarried was a risk factor against developing overweight in normal BMI MDD patients,while a higher level of education was a protective factor against developing MetS in overweight MDD patients.Conclusion MDD patients exhibited a higher intensity and risk of developing MetS,and it is not easy to reverse MetS,suggesting that BMI management and MetS intervention should be strengthened in MDD patients.
