Research progress in molecular typing and individualized therapy of paraganglioma
10.3781/j.issn.1000-7431.2024.2301-0022
- VernacularTitle:副神经节瘤分子分型及个体化治疗研究进展
- Author:
Shihui ZHANG
1
;
Susheng SHI
1
Author Information
1. 国家癌症中心,国家肿瘤临床医学研究中心,中国医学科学院北京协和医学院肿瘤医院病理科,北京 100021
- Publication Type:Journal Article
- Keywords:
Parasanglioma;
Pheochromocytoma;
Molecular typing;
Individualized therapy
- From:
Tumor
2024;44(5):528-535
- CountryChina
- Language:Chinese
-
Abstract:
Paraganglioma(PGL)is a neuroendocrine tumor,which can be divided into extradrenal paraganglioma and intradrenal paraganglioma according to its location.Together they are called PPGL(pheochromocytoma and paraganglioma).With the further study of its molecular biology,PPGL can be divided into three subtypes:pseudohypoxia-driven type,kinase pathway altered type and Wnt pathway altered type.Different subtypes of PPGL can provide different individualized treatments.In this paper,we review the recent advances in different molecular typing and individualized therapy of PPGL.
