Predictive value of contrast-enhanced ultrasound parameters combined with blood lipids for vulnerable carotid plaques in IS patients
10.3969/j.issn.1009-0126.2025.03.020
- VernacularTitle:超声造影联合血脂检测评价颈动脉易损斑块对缺血性脑卒中患者的预测价值
- Author:
Lingzhi LI
1
;
Heji WEI
;
Yanping LI
;
Minru HU
Author Information
1. 528211 佛山市南海区第四人民医院功能科
- Publication Type:Journal Article
- Keywords:
ultrasonography;
triglycerides;
lipoproteins;
carotid stenosis;
ROC curve
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(3):348-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of contrast-enhanced ultrasound(CEUS)pa-rameters combined with blood lipids in evaluating vulnerable carotid plaques in patients with is-chemic stroke.Methods A prospective trial was conducted on 120 patients diagnosed with vulner-able carotid plaques in our hospital from January 2023 to May 2024.According to having ischemic stroke or not,60 of them were assigned into ischemic stroke(study group),and the other 60 into control group.Routine ultrasound,CEUS and blood lipid examinations were performed respective-ly in the two groups.The unstable plaque integral ratio,maximum plaque length,maximum plaque thickness,ulceration plaque,area stenosis,peak velocity at stenosis,resistance index and blood lipid levels between the study group and the control group and in the study group with different blood flow grades were analyzed.ROC curve analysis was used to calculate the AUC value.Results There were statistical differences between the study group and the control group in terms of unstable plaque integral ratio,maximum plaque length,maximum plaque thickness,ulceration plaque,area stenosis,peak velocity at stenosis,resistance index and blood flow characteristics(P＜0.01).The study group had significantly higher TC,TG and LDL levels and lower HDL level than the control group(P＜0.01).Obvious differences were observed in unstable plaque integral ratio,maximum plaque length,maximum plaque thickness,ulceration plaque,area stenosis,peak velocity at stenosis and resistance index among the patients from the study group with different blood flow grades(P＜0.05,P＜0.01),so were their TC,TG,LDL and TG levels in them(P＜0.01).For above these patients,the TC,TG and LDL levels were gradually decreased,while that of HDL was increased in turn in the patients with blood flow grades Ⅲ,Ⅱ to Ⅰ(P＜0.01).The blood flow grade was positively correlated with TC,TG and LDL levels(r=0.456,r=0.652,r=0.362,P=0.000),while negatively with HDL level(r=-0.256,P=0.000).ROC curve analysis showed that the AUC value of the combination in the diagnosis was significantly higher than that detected by single detection.Cutoff analysis suggested that CEUS blood flow grade of over Ⅱ,and TC of 5.22 mmol/L,TG of 2.33 mmol/L,LDL of 2.78 mmol/L,and HDL of 0.82 mmol/L were the cutoff values in diagnosing vulnerable carotid plaque for ischemic stroke patients.Conclusion High grade of CEUS blood flow combined with abnormal blood lipid levels may serve as predic-tive indicators for ischemic stroke patients.
