Research progress on histone acetylation modifications in the occurrence and development of preeclampsia

VernacularTitle:组蛋白乙酰化修饰在子痫前期发生和发展中的研究进展
Author: Qian MA ¹ ; Xiaotong SUN ; Tao QU ; Qing YANG ; Xincong XU
Author Information

1. 甘肃中医药大学第一临床医学院，兰州　730000
Publication Type:Journal Article
Keywords: Pre-eclampsia; Epigenetic; Histone modification
From: Chinese Journal of Perinatal Medicine 2025;28(2):167-172
CountryChina
Language:Chinese
Abstract: The etiology of preeclampsia (PE) remains poorly understood. Recent years have seen deepening research into epigenetics, where acetylation modifications of histones have garnered significant attention for their roles in various diseases, particularly in tumor pathologies. Several studies have indicated a crucial role for histone 3 acetylation in PE and hypoxia. Additionally, abnormal expressions of histone deacetylases (HDACs) and/or histone acetyltransferases (HATs) are implicated in the pathogenesis and progression of PE. This review aims to analyze the changes in histone 3 in PE, as well as the mechanisms underlying HDACs and HATs and their upstream or downstream target genes in the disease to elucidate the role of histone acetylation modifications in PE. It also seeks to uncover the potential clinical value of histone acetylation modulatory inhibitors, particularly HDAC inhibitors, in PE.