Research advances on the genetic pathogenesis and gene therapy for pancreatitis
10.3760/cma.j.cn511374-20240814-00442
- VernacularTitle:胰腺炎遗传致病机制与基因治疗的研究进展
- Author:
Yizhou ZHENG
1
;
Yuanchen WANG
1
;
Wenbin ZOU
1
Author Information
1. 海军军医大学长海医院消化内科 上海市胰腺病研究所，上海 200433
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Susceptibility gene;
Genetic pathogenesis;
Gene therapy
- From:
Chinese Journal of Medical Genetics
2025;42(1):122-127
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatitis is an inflammatory disease influenced by both environmental and genetic factors. It has a high prevalence and mortality rate worldwide, with no radical cure. Breakthroughs have been recently made in genetic research of pancreatitis. Susceptibility genes and pathways have been continuously discovered, which highlighted the roles of genetic factors in hypertriglyceridemic and chronic pancreatitis. Gene therapy may offer radical cure for pancreatitis, though it has remained at the research phase. This article has reviewed the genetic pathogenesis of pancreatitis and current status of gene therapy research, with an aim to provide a reference for attaining definitive cure for the disease.
