Progress in research on the relationship between neurovascular unit changes and glaucoma
10.13389/j.cnki.rao.2025.0056
- VernacularTitle:视网膜神经血管单元改变与青光眼的关系研究进展
- Author:
Yujie LIU
1
;
Guangyu ZHU
;
Yue SUN
;
Xuejing LU
Author Information
1. 610075 四川省成都市,成都中医药大学眼科学院;610075 四川省成都市,中医药眼病防治与视功能保护四川省重点实验室
- Publication Type:Journal Article
- Keywords:
glaucoma;
neurovascular unit;
glial cells;
neurovascular coupling;
ocular glymphatic system
- From:
Recent Advances in Ophthalmology
2025;45(4):314-320,325
- CountryChina
- Language:Chinese
-
Abstract:
The significance of the retinal neurovascular unit(NVU)in glaucoma has been established,and it holds po-tential as an effective therapeutic target for neurodegenerative disorders such as glaucoma in the future.NVUs are a cell community composed of neurons,glial cells,and vascular cells,and they engage in the physiological and pathological inter-actions between retinal neurovasculature through neurovascular coupling(NVC).As a representative neurodegenerative disorder of the retina,glaucoma is closely associated with retinal microvasculature and glial cells,rendering the normal functioning of the NVU particularly crucial.In this paper,the structural foundation of the NVU was reviewed,including the leading and coordinating roles of retinal neurons and glial cells in the NVU,and the role of NVCs in regulating retinal blood flow,metabolism,and the clearance of toxic substances.Furthermore,the associations of the components of the NVU and their functional abnormalities with glaucoma were elucidated.This paper will deepen the understanding of the mechanisms of glaucoma from a neurovascular perspective,and provide new preventive directions or therapeutic targets for neuropro-tection in glaucoma.
