Research progress of pannexin 1 in infection
10.12138/j.issn.1671-9638.20256688
- VernacularTitle:泛连接蛋白1在感染中的研究进展
- Author:
Zhiwei XU
1
;
Pusen WANG
;
Shubin ZHANG
;
Lin ZHONG
Author Information
1. 深圳第三人民医院肝脏外科(肝移植),广东 深圳 518112;南京医科大学附属上海市第一人民医院肝胆外科,上海 201620
- Publication Type:Journal Article
- Keywords:
pannexin 1;
infection;
ATP;
purinergic receptor;
synthetic peptide;
PANX1
- From:
Chinese Journal of Infection Control
2025;24(3):430-436
- CountryChina
- Language:Chinese
-
Abstract:
Pannexin 1(PANX1)interacts with purinergic receptors through regulating immune responses,relea-sing adenosine triphosphate(ATP),and the NLRP3/caspase-1/interleukin(IL)-1β signaling pathway,then influ-ences the activation of immune cells and promotes the production of reactive oxygen species(ROS),thus causing in-flammation and tissue damage which exacerbates infection.This research group has synthesized new polypeptides named QE20 and EE20,which can specifically inhibit the opening of PANX1 channels under inflammatory stimula-tion,offering advantages such as reducing cellular ATP release,inhibiting inflammatory factor secretion,and pre-venting hepatocyte pyroptosis,et al.This review summarizes the roles and mechanisms of PANX1 in various infec-tious diseases,and predicts the feasibility of PANX1 as a potential therapeutic target in the future.
