Current perspectives and progress of application of botulinum toxin in lower urinary tract dysfunction in children
10.3760/cma.j.cn112330-20231220-00198
- VernacularTitle:肉毒毒素治疗儿童下尿路功能障碍的现状及研究进展
- Author:
Zhan WANG
1
;
Zhaokai ZHOU
1
;
Yibo WEN
1
;
Qingwei WANG
1
;
Jianguo WEN
1
Author Information
1. 郑州大学第一附属医院泌尿外科和小儿尿动力中心 河南省小儿尿动力国际联合实验室，郑州 450052
- Publication Type:Journal Article
- Keywords:
Children;
Botulinum toxin A;
Lower urinary tract dysfunction;
Overactive bladder;
Detrusor overactivity;
Dystrusor external sphincter dysynergia
- From:
Chinese Journal of Urology
2025;46(4):316-320
- CountryChina
- Language:Chinese
-
Abstract:
Lower urinary tract dysfunction (LUTD) is common in children, but treatment is difficult in some cases, and it might causes upper urinary tract damage in the late stage. Recently, botulinum toxin A(BTX-A) has been recommended as an effective procedure for refractory LUTD, which has significantly improved symptoms and reduced the occurrence of upper urinary tract damage in children with LUTD. At present, there is a lack of international consensus on the application indication and dose selection of BTX-A in LUTD children, and the safety and long-term efficacy of repeated BTX-A injection are also clinical concerns. This article reviews the current application perspectives and progress of BTX-A in the treatment of children with LUTD, especially the clinical application indications and methods.BTX-A provides a minimally invasive, safe and effective treatment option for children with LUTD, which can significantly improve clinical symptoms and urodynamic parameters. With the further clarification of indications and the improvement of administration methods, BTX-A will be able to assist more children with LUTD in enhancing their quality of life and lessening their physical and mental burden.
