The research progress of ubiquitination and deubiquitination in castration-resistant prostate cancer
- VernacularTitle:泛素化和去泛素化修饰在去势抵抗性前列腺癌中的研究进展
- Author:
Engui YANG
1
;
Chen GONG
1
;
Zhiyong TAN
1
;
Yinglong HUANG
1
;
Senmao LI
1
;
Haihao LI
1
;
Haifeng WANG
1
;
Mingxia DING
1
Author Information
- Publication Type:Journal Article
- Keywords: Prostatic neoplasms; Carcinoma; Ubiquitination; Castration resistance; Androgen receptor
- From: Chinese Journal of Urology 2025;46(4):312-315
- CountryChina
- Language:Chinese
- Abstract: The treatment of castration-resistant prostate cancer (CRPC) faces major challenges characterized by acquired resistance to androgen deprivation therapy (ADT) and consequent aggressive tumor progression. In this context, ubiquitination and deubiquitination modifications, as key protein post-translational modifications, play a crucial role in prostate tumourigenesis and progression. In recent years, the regulation of ubiquitination and deubiquitination in CRPC by the androgen receptor signalling pathway and the tumour microenvironment has received extensive attention, and these dynamic regulatory processes have become important molecular events driving CRPC progression by affecting the proliferation, metastasis, and immune escape ability of tumour cells. Therefore, in-depth analysis of the mechanisms of ubiquitination and deubiquitination in CRPC will help develop new therapeutic targets and provide more therapeutic options for patients.
