The dynamic patterns of intrinsic neural activity in individuals with internet gaming disorder: a resting state functional magnetic resonance imaging study
10.3760/cma.j.cn113661-20230328-00064
- VernacularTitle:网络游戏障碍患者大脑内在神经活动动态模式改变的静息态功能磁共振成像研究
- Author:
Xiaoyu NIU
1
;
Xinyu GAO
1
;
Mengzhe ZHANG
1
;
Jinghan DANG
1
;
Jieping SUN
1
;
Weijian WANG
1
;
Yong ZHANG
1
;
Jingliang CHENG
1
Author Information
1. 郑州大学第一附属医院磁共振科，郑州450002
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Internet gaming disorder;
Dynamic regional homogeneity;
Fronto-striato-thalamic circuit
- From:
Chinese Journal of Psychiatry
2024;57(2):87-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to investigate the dynamic patterns of intrinsic neural activity and their relationships with Internet Addiction Test (IAT) scores in individuals with internet gaming disorder (IGD).Methods:Resting state functional magnetic resonance imaging (fMRI) scanning was performed on 33 individuals with IGD (IGD group) who were admitted to the psychiatric department of First Affiliated Hospital of Zhengzhou University and 40 healthy volunteers (control group) recruited through the online platform. The dynamic regional homogeneity (dReHo) values were calculated. The two-sample t test was used to analyze the differences of dReHo values between two groups (Gaussian random field corrected, voxel level P<0.001, cluster level P<0.05). Spearman correlation analyses were used to analyze the correlations between IAT scores and dReHo values of brain regions with statistically significant differences between IGD group and control group. Results:Compared with the control group, the IGD group showed increased dReHo values in the right thalamus, right caudate nucleus, left putamen, bilateral medial superior frontal gyrus, bilateral supplementary motor area, and bilateral superior frontal gyrus ( t=3.84-4.94, Gaussian random field corrected, voxel level P<0.001, cluster level P<0.05). The dReHo value in the right medial superior frontal gyrus was positively correlated with IAT scores ( r=0.395, P=0.023) in IGD group. Conclusion:Individuals with IGD exhibited a wide range of abnormal dynamic patterns of intrinsic neural activity in pivotal regions associated with reward processing and cognitive control functions (the fronto-striato-thalamic circuit), providing new insights into the underlying neural mechanisms of IGD.
