The investigation of limbic network dysfunction across three clinical phases of bipolar disorder
10.3760/cma.j.cn113661-20230817-00034
- VernacularTitle:双相障碍三种临床相边缘系统网络功能异常的研究
- Author:
Dongsheng LYU
1
;
Wuhong LIN
;
Zhening LIU
;
Weidan PU
;
Ping YAO
;
Xuyi WANG
;
Wenbin GUO
;
Jingping ZHAO
Author Information
1. 中南大学湘雅二医院精神科 国家精神疾病医学中心 国家精神心理疾病临床医学研究中心，长沙410011
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Limbic system;
Magnetic resonance imaging;
Functional connectivity;
Amplitude of low-frequency fluctuation
- From:
Chinese Journal of Psychiatry
2024;57(2):78-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The present study aims to investigate whether there is a shared alteration of the resting-state functional connectivity and amplitude of low frequency fluctuation (ALFF) within the limbic network across all three clinical phases of bipolar disorder.Methods:From July 2019 to December 2021, 107 patients diagnosed with bipolar disorder (bipolar disorder group) were recruited from the Institute of Mental Health at Xiangya Second Hospital, Central South University. Additionally, 46 healthy controls matched for age, gender, and education level were enrolled as the control group. According to the total scores of the Young Mania Rating Scale (YMRS) and the Hamilton Depression Rating Scale (HAMD 17), individuals with bipolar disorder can be categorized into three groups: bipolar manic group, bipolar depressive group, and bipolar euthymic group. Resting state functional magnetic resonance imaging data were collected from all the participants, and seed-based functional connectivity and ALFF in the limbic network were conducted to compare differences among three mood states and controls using One-way ANOVA and post hoc analysis. Finally, correlation analyses using Pearson or Spearman coefficients were performed between statistically significant intergroup differences in functional connectivity/ALFF values and total scores as well as factor scores on clinical rating scales. Results:In comparison to the healthy controls, there was a significant decrease in functional connectivity between the anterior cingulate gyrus and hippocampus across all three clinical phases of bipolar disorder after Bonferroni correction ( t=-2.60--2.07, P<0.05). Furthermore, the ALFF in the anterior cingulate gyrus during three phases showed a significantl reduction following false discovery rate correction ( t=-4.41--3.51, P<0.05). Moreover, a decreased functional connectivity between the left anterior cingulate gyrus and left hippocampus during the depressive phase demonstrated a significant negative correlation with work interest subscores of the HAMD 17 ( r=-0.406, P=0.021). Conclusions:Dysconnectivity and reduced activity within the anterior cingulate of the limbic network may represent common alterations of mood regulation disorder throughout all three clinical phases of bipolar disorder.
