Analysis of the interactive effects between smoking addiction and overweight on brain gray matter volume
10.3760/cma.j.cn113661-20230728-00018
- VernacularTitle:吸烟成瘾及超重间交互作用与脑灰质体积的相关性分析
- Author:
Mengzhe ZHANG
1
;
Xiaoyu NIU
1
;
Jinghan DANG
1
;
Jieping SUN
1
;
Weijian WANG
1
;
Jingliang CHENG
1
;
Yong ZHANG
1
Author Information
1. 郑州大学第一附属医院磁共振科，郑州450052
- Publication Type:Journal Article
- Keywords:
Behavior, addictive;
Smoking;
Overweight;
Interaction;
Gray matter volume;
Voxel-based morphometry
- From:
Chinese Journal of Psychiatry
2024;57(7):433-439
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between brain gray matter volume (GMV) and interactive effects of smoking addiction and overweight.Methods:We retrospectively analyzed the clinical data and resting-state functional magnetic resonance imaging data of 99 subjects recruited from January 2019 to December 2021 through online platforms such as WeChat, including the following four groups: overweight smoking addiction group ( n=24), normal-weight smoking addiction group ( n=28), overweight non-smoking group ( n=19), and normal-weight non-smoking group ( n=28). All subjects underwent 3.0T MRI. We used voxel-based morphometry (VBM) to compare gray matter volume (GMV) among the four groups. A two-way analysis of variance was conducted with age, years of education, and head motion as covariates to explore the interaction effects between smoking addiction and weight status on GMV, the main effect of smoking addiction and main effect of overweight, which were then correlated with clinical data. Results:Significant interactive effects of smoking addiction and overweight were observed in the left dorsolateral prefrontal cortex (DLPFC) (GRF corrected, voxel-level P<0.001, cluster-level P<0.05). Correlation analysis showed a quadratic effect between body mass index and left DLPFC GMV (β=-3.846, t=-2.134, P=0.036). Additionally, the main effect of smoking addiction was primarily manifested in the bilateral orbitofrontal cortex (OFC)(GRF corrected, P voxel<0.001, P cluster<0.05). Left OFC GMV was negatively associated with the FTND (Fagerstrom Test of Nicotine Dependence) scores ( r=-0.391, P=0.006). And right OFC GMV was negatively correlated with the smoking index ( r=-0.335, P=0.019). No statistically significant main effect of overweight was found at the aforementioned threshold. Conclusion:Smoking addiction and overweight have antagonistic effects on left DLPFC GMV.
