Two cases of serotonin syndrome caused by paroxetine combined with bupropion
10.3760/cma.j.cn113661-20231025-00156
- VernacularTitle:帕罗西汀联合安非他酮致5-羟色胺综合征2例
- Author:
Xiaoxi LIU
1
;
Yonggui YUAN
Author Information
1. 临沂市中心医院精神卫生科，临沂276400
- Publication Type:Journal Article
- Keywords:
Paroxetine;
Bupropion;
Serotonin syndrome
- From:
Chinese Journal of Psychiatry
2024;57(2):105-107
- CountryChina
- Language:Chinese
-
Abstract:
Serotonin syndrome (SS) is an infrequent drug-induced syndrome resulting from excessive 5-HT levels in the central and peripheral nervous system due to drug administration and interactions, commonly observed following the utilization of 5-HTergic drugs or concurrent use of monoamine oxidase inhibitors (MAOI) with 5-HTergic agents. There is a case report on the management of two patients with SS who received combination therapy of paroxetine and bupropion. Given its rapid progression and potential fatality in severe instances, healthcare professionals are reminded to promptly recognize early symptoms and mitigate serious consequences when co-administering such medications.
