Latest Research Progress on Dual Regulatory Mechanisms of Matrix Metalloproteinase 3 in Skeletal System
10.3969/j.issn.1671-7414.2025.02.039
- VernacularTitle:基质金属蛋白酶3在骨骼系统中双重调控作用机制的最新研究进展
- Author:
Yi LIU
1
;
Heping ZHAO
1
;
Xi QI
1
;
Yan YU
1
Author Information
1. 西安交通大学附属红会医院检验科,西安 710054
- Publication Type:Journal Article
- Keywords:
matrix metalloproteinase 3;
dual regulatory;
osteoarticular diseases;
wound healing
- From:
Journal of Modern Laboratory Medicine
2025;40(2):208-213,220
- CountryChina
- Language:Chinese
-
Abstract:
With the increasing problem of an aging population,the incidence of osteoarticular diseases such as rheumatoid arthritis(RA),osteoarthritis(OA),ankylosing spondylitis(AS)and osteoporosis(OP)is gradually rising.Matrix metalloproteinase 3(MMP-3),as an important member of the matrix metalloproteinases(MMPs)family,plays a dual regulatory role.On one hand,it is involved in pathological processes such as cartilage damage and joint dysfunction,exerting a negative regulatory effect in the occurrence and progression of various osteoarticular diseases.On the other hand,MMP-3 has positive regulatory effects in early embryonic layer differentiation,craniofacial bone formation,neuronal axon regeneration,cartilage ossification,and adipocyte differentiation.This article reviewed the structure and function of MMP-3 as well as its negative regulatory roles in diseases such as in RA,OA,AS and OP,while exploring its positive regulatory roles in growth,development and wound healing.The article also analyzed the dual regulatory mechanisms of MMP-3 in bone and joint diseases,and summarized the research progress of MMP-3 inhibitors,in order to provide new ideas and insights for related clinical research.
