Effect of dredging pulmonary collaterals treatment on the level of IL-1β in induced sputum in patients with refractory asthma
10.3760/cma.j.cn311847-20211224-00357
- VernacularTitle:搜剔肺络法对难治性哮喘患者诱导痰IL-1β水平的影响
- Author:
Yanping DONG
1
;
Yada ZHANG
;
Binqing TANG
Author Information
1. 上海中医药大学附属岳阳中西医结合医院老年科，上海 200437
- Publication Type:Journal Article
- Keywords:
Dredging pulmonary collaterals treatment;
Refractory asthma;
Interleukin-1β
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(3):375-379
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the efficacy of dredging pulmonary collaterals treatment（Suzi Jiangqi decoction plus Scolopendra and Scorpio）on the level of IL-1β in induced sputum in patients with refractory asthma. Methods:A total of 60 patients with refractory asthma，admitted to the two affiliated hospitals of Shanghai University of Tradition Chinese Medicine，were randomly assigned to control group and treatment group. Both groups were given aerosol inhalation of salmeterol，fluticasone，and tiotropium bromide. Additionally，the control group was given Suzi Jiangqi decoction，while the treatment group was given Suzi Jiangqi decoction plus Scolopendra and Scorpio. Both groups were treated for 12 weeks. Asthma control test（ACT）scores，IL-1β levels in induced sputum，and safety indicators such as complete blood count，and lung，liver，and renal functions were compared between the two groups. Results:After treatment，the ACT score，the forced expiratory volume in the first second（FEV 1.0），and the ratio of FEV 1.0 to the forced vital capacity（FEV 1.0/FVC）all increased，while the IL-1β levels decreased in both two groups. And the treatment group had significantly better improvements in the above-mentioned items than the control group，all with statistically significant differences（ P<0.05 or P<0.01）. Before and after treatment，there was no obvious change in the level of eosinophil in peripheral blood in either group. After treatment，all the safety indicators were within normal ranges in both groups. Conclusion:Suzi Jiangqi decoction plus Scolopendra and Scorpio can effectively control the severity of asthma and improve the lung function in patients with refractory asthma by reducing the level of IL-1β in induced sputum，the mechanism of action may be related to the inhibition of cell pyroptosis.
