A preliminary observation of resting-state functional connectivity of bilateral amygdale in drug-naive patients with obsessive-compulsive disorder
10.3760/cma.j.cn113661-20190707-00219
- VernacularTitle:未服药强迫症患者双侧杏仁核静息态功能连接的初步观察
- Author:
Yunhui CHEN
1
;
Ping LI
;
Dan LYU
;
Cuicui JIA
;
Guangfeng ZHANG
;
Yuhua WANG
;
Zhenghai SUN
;
Wei WANG
;
Yefu WANG
;
Yu GUO
Author Information
1. 齐齐哈尔医学院精神卫生学院临床心理教研室 161006
- Publication Type:Journal Article
- Keywords:
Obsessive-compulsive disorder;
Amygdala;
Magnetic resonance imaging;
Emotional regulation network
- From:
Chinese Journal of Psychiatry
2020;53(2):122-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the pattern of resting-state functional connectivity of bilateral amygdale in drug-naive obsessive-compulsive disorder (OCD).Methods:Forty patients with OCD matched the criteria of International Classification of Diseases-10 and 38 gender-, age-, education-matched healthy subjects participated in the resting-state brain functional magnetic resonance imaging scan. The Yale-Brown Obsessive-Compulsive Scale, 17-Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale (HAMA) were used to assess the clinical symptoms of obsession, compulsion, depression and anxiety. Based on the Data Processing & Analysis for (Resting-State) Brain Imaging software, a voxel-based functional connectivity approach was used to explore the pattern of resting-state functional connectivity of bilateral amygdala in OCD; Pearson correlation analyses was used to analyze the relationship between the abnormal functional connectivity values and clinical symptoms in OCD.Results:Compared with the controls, patients with OCD showed decreased functional connectivity values between left amygdale and right dorsal anterior insula (0.16±0.13 vs. 0.27±0.13, t=-2.75, P<0.05, Gaussian random field (GRF) corrected, two-tailed), and between left amygdale and left ventral anterior cingulate cortex (0.09±0.12 vs. 0.19±0.13, t=-3.40, P<0.05, GRF corrected, two-tailed). The functional connectivity between left amygdale and right dorsal anterior insula was positively correlated with HAMA total score ( r=0.377, P=0.016, uncorrected). Conclusions:At resting-state, the functional connectivities of the emotional regulation network decreased in drug-naive patients with OCD. Decreased functional connection between left amygdale and right dorsal anterior insula may be associated with anxiety symptoms in patients with OCD.
