Thrombocytopenia in Liver Cirrhotic Patients Induced by Linezolid
10.3870/j.issn.1004-0781.2025.04.027
- VernacularTitle:利奈唑胺致肝硬化患者血小板降低的药学监护
- Author:
Shanshan ZHU
1
;
Bo ZHANG
;
Kexing ZHANG
;
Mingming MA
Author Information
1. 黑龙江省医院药学部,哈尔滨 150036
- Publication Type:Journal Article
- Keywords:
Linezolid;
Liver cirrhosis;
Thrombocytopenia;
Serum drug concentration monitoring
- From:
Herald of Medicine
2025;44(4):673-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors and countermeasures of linezolid-induced thrombocytopenia.Methods Clinical pharmacists participated in the pharmacy practice of linezolid-induced thrombocytopenia in a patient with liver cirrhosis.They analyzed the risk factors,took timely countermeasures,and conducted pharmaceutical care.Results The liver cirrhosis,low creatinine clearance and basic platelet values were closely related to linezolid-related thrombocytopenia,platelet recovered after discontinuation.Linezolid(0.3 g,Ⅳ,q12h)was used again under serum drug concentration monitoring,and the infection was effectively controlled,no thrombocytopenia occurred.Conclusions Clinical pharmacists should conduct pharmaceutical care for patients,pay close attention to adverse reactions,and timely adjust the treatment plan to better ensure the effectiveness and safety of treatment.
