Preparation and Prescription Optimization of Alcoholsome by Cortex Dictamni-Fructus Kochiae
10.3870/j.issn.1004-0781.2025.04.022
- VernacularTitle:白鲜皮-地肤子药对醇质体的制备及处方优化
- Author:
Jingjing JIANG
1
;
Jiangwei LYU
;
Shuo YANG
;
Yonglin CHEN
;
Jiang XIA
;
Hao WANG
;
Wenjun ZHANG
Author Information
1. 哈尔滨商业大学药学院,哈尔滨 150076
- Publication Type:Journal Article
- Keywords:
Cortex dictamni;
Fructus kochiae;
Ethosome;
Prescription optimization
- From:
Herald of Medicine
2025;44(4):639-647
- CountryChina
- Language:Chinese
-
Abstract:
Objective The optimum formulation process was selected to prepare the ethosomes of Cortex Dictamni-Fructus Kochiae,and its prescription was verified and its properties were studied.Methods The formulation was optimized by single factor and response surface test.The appearance,particle size,Zeta potential and stability were investigated.The encapsulation rate was used as the evaluation index.Results The optimum preparation process of ethosomes of Cortex Dictamni-Fructus Kochiae is as follows:Using the dosage of lyophilized powder 409.06 mg,soybean lecithin 258.07 mg,cholesterol 90.87 mg,ethanol volume fraction 22.76％,stirred for 2 hours at 700 r·min-1 at 50 ℃ water bath temperature,The appearance of the prepared ethosomes suspension was light yellow,and the particles were nearly spherical in shape.The average particle size was(103.1±0.78)nm,the Zeta potential was(-36.0±3.65)mV,and the average encapsulation rates of Xibutanone,ash,and saponin Ⅰc were(89.25±0.91)％,(80.16±1.52)％,(86.59±0.58)％,respectively.After 14 days of storage at room temperature,the results showed that:The ethosomal suspension is still a light yellow,uniform,and stable liquid,and there is no stratified precipitation phenomenon.Conclusion The method of ethanol injection is easy to operate,high encapsulation rate and good stability,which lays a foundation for further study on the skin administration of this preparation.
