Brain imaging characteristics of inhibition dysfunction in patients with obsessive-compulsive disorder
10.3760/cma.j.cn113661-20190730-00252
- VernacularTitle:强迫症患者抑制功能受损的脑影像学特征
- Author:
Mingtian ZHONG
1
;
Bowen ZHANG
;
Changlian TAN
;
Xingwei LUO
;
Xiongzhao ZHU
;
Jinyao YI
Author Information
1. 华南师范大学心理学院心理应用研究中心 心理健康与认知科学广东重点实验室，广州 510631
- Publication Type:Journal Article
- Keywords:
Obsessive-compulsive disorder;
Inhibition (Psychology);
Go-Nogo task;
Error monitoring
- From:
Chinese Journal of Psychiatry
2020;53(2):111-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to explore whether there is impaired inhibition function and the brain imaging characteristics of inhibition dysfunction in patients with obsessive-compulsive disorder (OCD).Methods:A total of 16 drug-naive OCD patients and 18 healthy controls (HC) completed the Go-Nogo task to detect the impairment of inhibition function, and the task-related brain magnetic resonance imaging were collected. The differences of average reaction time and correct response rate between OCD patients and HC under Go and Nogo conditions were compared, and the differences of brain activation between the two groups in the process of successful response inhibition and error monitoring were also compared.Results:Under Nogo condition, the average correct rate in patients with OCD was significantly lower than that of HC (0.85±0.08 vs.0.93±0.51; t=-3.06, P<0.05). In error processing analysis, patients with OCD showed significantly enhanced brain activities in bilateral inferiortemporal (left: t=3.11; right: t=2.71), right middlefronta ( t=2.52), right parahippocampa ( t=2.53), and left posteriorcingulate ( t=3.03), while decreased brain activities were found in bilateral putamen (left: t=-3.03; right: t=-3.12), right inferiorfrontal ( t=-3.29), right superiorfrontal ( t=-3.12), and right precentral ( t=-2.91) compared with control group ( P<0.05, FWE corrected, cluster size>10 voxels). Conclusion:Patients with OCD have impaired inhibition function, and their abnormal brain function is mainly manifested in the process of error monitoring.
