Study on the anti-motion sickness effect of atrial natriuretic peptide in rats
10.3760/cma.j.cn311847-20220226-00072
- VernacularTitle:心房钠尿肽的抗大鼠运动病作用研究
- Author:
Chang REN
1
;
Shuifeng XIAO
1
;
Lihua XU
1
;
Xin ZHOU
1
;
Guohua WANG
1
;
Zhenglin JIANG
1
Author Information
1. 南通大学特种医学研究院，南通 226019
- Publication Type:Journal Article
- Keywords:
Rat;
Motion sickness;
Arginine vasopressin;
Atrial natriuretic peptide
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(5):582-586
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the anti-motion sickness effect of atrial natriuretic peptide（ANP）through establishing two types of motion sickness rat models by giving rotational stimulation or intraperitoneal arginine vasopressin（AVP）injection.Methods:Normal Sprague-Dawley rats were rotated 120 min to induce motion sickness. The behavioural changes in their ingestion of 0.15% saccharin sodium solution（SSS）and consumption of kaolin were measured；and the susceptibilities of the rats to motion sickness were thus determined. The behavioural changes in the ingestion of 0.15% SSS after the intraperitoneal injection of AVP were also recorded. Finally，after the intraperitoneal injection of ANP，inhibitory influences on taste aversion to 0.15% SSS induced by these two methods were determined.Results:After the rotational stimulation，the rats reduced their intake of 0.15% SSS（taste aversion）or increased the intake of kaolin（pica）. The intraperitoneal injection of AVP in rats could also induce taste aversion to 0.15% SSS. However，the intraperitoneal injection of ANP effectively inhibited this conditioned taste aversion to 0.15% SSS induced either by rotational stimulation or AVP injection.Conclusion:Both rotational stimulation and intraperitoneal injection of AVP could induce motion sickness；and the intraperitoneal injection of ANP could help relieve motion sickness in rats.
