Research Progress of Colitis Microenvironment-Responsive Polymer Drug Delivery System in the Treatment of Colitis
10.3870/j.issn.1004-0781.2025.04.017
- VernacularTitle:结肠炎微环境响应型聚合物药物递送系统在结肠炎治疗中的研究进展
- Author:
Zhigang WEI
1
;
Yuhong LIN
;
Jingan WANG
;
Shangen XU
;
Kai ZHAO
Author Information
1. 农业微生物技术教育部工程研究中心,黑龙江省寒区植物基因与生物发酵重点实验室,黑龙江大学生命科学学院,哈尔滨 150080
- Publication Type:Journal Article
- Keywords:
Polymer;
Colitis microenvironment;
Stimuli-responsive;
Drug-delivery system;
Targeted therapy
- From:
Herald of Medicine
2025;44(4):603-610
- CountryChina
- Language:Chinese
-
Abstract:
As common drug delivery materials,polymers possess the advantages of a simple preparation method,adjustable chemical structure,and excellent biocompatibility.They are widely used in the responsive drug delivery for various diseases,especially in drug delivery of colon diseases.Utilizing the adjustable characteristics of polymers,drug delivery systems based on pH response,microbial enzyme response,reactive oxygen species response,and bio-adhesion have been constructed,showing excellent efficacy in the treatment of colitis.This article reviews the research progress of polymer-based targeted drug delivery systems in the treatment of colitis and discusses its research and application prospects.
