Research progress of Kupffer cell subsets and their functions
10.3969/j.issn.1000-484X.2025.03.039
- VernacularTitle:枯否细胞亚群与功能的研究进展
- Author:
Sai ZHAO
1
;
Qian YU
;
Liangming LIU
Author Information
1. 南京医科大学上海松江临床医学院,上海 201600
- Publication Type:Journal Article
- Keywords:
Kupffer cells;
Cell polarization;
Cell surface markers;
Single-cell RNA sequencing
- From:
Chinese Journal of Immunology
2025;41(3):733-739
- CountryChina
- Language:Chinese
-
Abstract:
Kupffer cells(KC),the hepatic resident macrophages,are located in the sinusoids,and play a crucial role in clearing intestinal-derived pathogens and damaged red blood cells,regulating iron and fat metabolism,and maintaining immune toler-ance.In acute and chronic hepatopathy,KC are implicated in liver injury and repair by crosstalk between other hepatocellular popula-tions such as hepatocytes,endothelial cells,hepatic stellate cells and so on,by which maintain liver homeostasis.KC are highly plas-tic,and different liver disease models and different hepatic microenvironmental signals can induce changes in the phenotype and func-tion of hepatic macrophages.In this review,we summarize the subsets of KC and their functions in specific liver disease models based on cell origin,cell polarization,cell surface markers,and gene expression profiles identified by single-cell sequencing techniques.We are aiming to target specific KC subsets to prevent or treat related liver diseases,and promote the progress of precision medicine for liver diseases.
