Explore the causal relationship between the gut microbiota and inflammatory bowel disease based on two-sample Mendelian randomization
10.3969/j.issn.1673-9701.2025.30.002
- VernacularTitle:基于两样本孟德尔随机化探究肠道菌群与炎症性肠病的因果关系
- Author:
Xiaoxu HUANG
1
;
Xiangdang HU
1
;
Qixuan HUANG
1
;
Yang WU
1
Author Information
1. 湖南中医药大学第二附属医院肛肠四科,湖南长沙 410005
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Gut microbiota;
Mendelian randomization;
Causal relationship
- From:
China Modern Doctor
2025;63(30):5-10,84
- CountryChina
- Language:Chinese
-
Abstract:
Objective Two-sample Mendelian randomization(TSMR)was used to explore the causal relationship between inflammatory bowel disease(IBD)and gut microbiota(GM).Methods GM was taken as the exposure factor,and two subtypes of IBD,Crohn's disease(CD)and ulcerative colitis(UC),were selected as the outcome factors.The potential causal relationship between IBD and gut microbiota was screened by TSMR statistical method.Results The results of comprehensive multiple analysis showed that 15 kinds of intestinal microbiota might be related to IBD.Among them,the Gastroenterococcaceae,Eulogicum,Clostridium 1,Agnobacter,Ruminococcus 2 and Ruminococcaceae UCG009 may be potential protective factors for IBD(OR＜1,P＜0.05);The UCG-011 of the Alfalfa family,the UCG001 of the Clostridium genus,the Actinobacillus genus,the Trichoderma genus,the Rumen genus UCG014,the NB1n order,the Eubacterium genus,the UCG008 of the Trichoderma family and the Clostridium order may be potential risk factors for IBD(OR＞1,P＜0.05);No pleiotropy or significant heterogeneity of instrumental variables genes was found.Conclusion The intestinal flora may have a dual effect on IBD.It may be a protective factor or increase the risk of IBD.The specific mechanism of action still needs to be further explored.
