Correlation between skeletal muscle mass index and islet β cell reserve function in patients with newly diagnosed type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.03.008
- VernacularTitle:新诊断2型糖尿病患者骨骼肌质量指数与胰岛β细胞储备功能相关性的研究
- Author:
Yalei FAN
1
;
Guirong BAI
;
Bingqian DING
;
Xindu LI
;
Tingting ZHU
;
Juan HE
;
Xiaojuan ZHANG
;
Xiaomin XIE
Author Information
1. 750004 银川,宁夏医科大学第二临床医学院
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Skeletal muscle mass index;
Fasting C-peptide;
Islet β cell function
- From:
Chinese Journal of Diabetes
2025;33(3):200-204
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between skeletal muscle mass index(ASMI)and islet β cell reserve function in patients with newly diagnosed type 2 diabetes mellitus(T2DM).Methods A total of 100 patients with newly diagnosed T2DM were included in this study.All the patients were admitted to the Department of Endocrinology in the First People's Hospital of Yinchuan between June 2022 and November 2023.They were divided into two groups according to their skeletal muscle mass index(ASMI):patients with T2DM accompanied by sarcopenia(Sar,n=50)group,and patients with simple T2DM(T2DM,n=50)group.Additionally,a control(NC)group consisting of 50 healthy participants was selected.Fasting C-peptide levels,liver and kidney function,blood lipid profiles,and other indicators were assessed in all the individuals.The correlation between ASMI and other indicators was analyzed,and the influencing factors for ASMI and T2DM combined with sarcopenia were analyzed respectively.Results The levels of HbA1c,FPG,and TG were higher,while FC-P and Scr levels were lower in the T2DM group and Sar group compared with the NC group(P<0.05).FPG was higher,while ASMI,FC-P,BMI were lower in the Sar group than in the T2DM group(P<0.05).Spearman correlation analysis revealed a negative correlation between ASMI and FPG and HbA1c(P<0.05),whereas a positive correlation was observed with BMI,ALT,Scr,SUA and FC-P(P<0.05).Multiple linear regression analysis indicated that BMI,HbA1c and FC-P were influencing factors for ASMI(P<0.05).Furthermore,logistic regression analysis demonstrated that BMI,HbA1c,FC-P were influencing factors for T2DM with sarcopenia(P<0.05).Conclusions The level of ASMI may be related to the reserve function of islet β cells.
