Aberrant anatomical brain network in first-episode schizophrenia and their healthy siblings
10.3760/cma.j.issn.1006-7884.2015.01.004
- VernacularTitle:精神分裂症首次发病患者及其健康同胞的脑结构网络研究
- Author:
Xiaofeng GUO
1
;
Junjie ZHENG
;
Jingfeng QI
;
Maorong HU
;
Huafu CHEN
;
Jingping ZHAO
Author Information
1. 中南大学湘雅二医院精神卫生研究所精神疾病诊治技术国家地方联合工程实验室精神病学与精神卫生学湖南省重点实验室,长沙,410011
- Publication Type:Journal Article
- Keywords:
Schizophrenia patients;
Healthy siblings;
White matter;
Anatomical network
- From:
Chinese Journal of Psychiatry
2015;48(1):12-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether the aberrant white matter network is shared by patients with schizophrenia and their healthy siblings.Methods Fourteen-three first-episode,treatment-naive patients with schizophrenia (patients),40 healthy siblings (siblings),and 55 healthy controls (controls)were scanned with 3.0T MRI scanner and diffusion tensor imaging tractography was used to construct the whiter matter brain network.The differences of white matter network were compared with analysis of variance among the 3 groups.Results The white matter network connectivity strength and the global efficiency significantly reduced in both patients (5.14 ±0.36,0.25 ±0.02) and their siblings (5.25 ±0.27,0.25 ±0.01) comparing to controls (5.41 ± 0.24,0.26 ± 0.01 ; F =16.55 P ＜ 0.01),without significant difference between patients and siblings (P ＞ 0.05).The degree in left precuneus,left anterior cingulate and right orbitofrontal gyrus was significantly lower in patients (7.42 ± 1.04,7.58 ± 1.25 and 3.72 ± 1.46)and siblings (7.51 ± 1.18,7.87 ± 1.10 and 4.42 ± 1.09) than controls (8.22 ± 1.07,8.31 ±0.99 and 4.80 ±0.92,P ＜0.05,FDR corrected); patients was also lower than siblings in right orhitofrontal gyrus (P ＜ 0.05,FDR corrected).Additionally significantly reduced betweenness centrality in left precuneus,left anterior cingulate and right orbitofrontal gyrus in patients (0.31 ± 0.02,0.32 ± 0.03 and 0.25 ± 0.03) and siblings (0.31 ±0.02,0.33 ±0.02 and 0.27 ±0.03) compared to controls (0.32 ±0.02,0.34 ± 0.02and 0.28 ± 0.02,P ＜ 0.05,FDR corrected) ; patients was also lower than siblings in right orbitofrontal gyrus (P ＜ 0.05,FDR corrected).Conclusions These findings suggest that schizophrenia patients and their healthy siblings share the aberrant white matter network,which may be the susceptibility biological marker for schizophrenia.
