Exploring the Treatment of Neurodegenerative Diseases From the Spleen:Based on The lmbalance of"lntestinal Flora-Mitochondria-Lipid Metabolism"
- VernacularTitle:基于"肠道菌群-线粒体-脂质代谢"失衡探讨"从脾论治"神经退行性疾病
- Author:
Chiyuan MA
1
;
Chenfei HE
;
Xinzhi WANG
;
Xiangzhe LIU
Author Information
- Publication Type:Journal Article
- Keywords: Neurodegenerative diseases; Treatment from spleen; Intestinal flora; Lipid metabolism; Mitochondria
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(3):762-769
- CountryChina
- Language:Chinese
- Abstract: Neurodegenerative diseases are chronic and progressive diseases of the nervous system.Modern studies have shown that intestinal flora disorders,mitochondrial dysfunction and lipid metabolism abnormalities are closely related to the occurrence and development of neurodegenerative diseases,but the treatment methods are limited.Traditional Chinese medicine believes that spleen is the"the foundation of nurture"and the"the source of Qi and blood biochemistry",Qi deficiency leads to insufficient Qi,blood and body fluid metaplasia,brain dysplasia,leading to the occurrence of neurodegenerative diseases.This paper discusses the mechanism of treating neurodegenerative diseases by spleen from the perspective of"intestinal flora,mitochondria and lipids",and concludes that intestinal flora balance is the material basis of spleen function,mitochondrial homeostasis is an important mechanism of the function of"spleen governing transportation and transformation",and abnormal lipid metabolism is an important manifestation of spleen deficiency and phlegm stasis.Intestinal flora,mitochondria and lipid metabolism may be the potential biological basis for the treatment of neurodegenerative diseases by spleen in traditional Chinese medicine.In order to provide ideas for the clinical research and treatment of neurodegenerative diseases.
