Molecular imaging studies of atherosclerotic vulnerable plaques:progress,challenges and prospects
10.3969/j.issn.1004-8812.2025.04.005
- VernacularTitle:动脉粥样硬化易损斑块分子影像探针研究:进展、挑战与展望
- Author:
Xi ZHANG
1
;
Hao-yi YE
;
Si-mei CUI
;
Wei WANG
;
Lei GAO
Author Information
1. 中国人民解放军总医院第六医学中心心血管病医学部,北京 100853;中国人民解放军医学院,北京 100853
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Vulnerable plaque;
Molecular imaging
- From:
Chinese Journal of Interventional Cardiology
2025;33(4):215-221
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis(AS)is the major pathologic basis of cardiovascular disease,and its complications,such as myocardial infarction and stroke,are primarily triggered by rupture of atherosclerotic vulnerable plaques(VASPs).Conventional imaging techniques rely on anatomical changes,making it difficult to assess plaque vulnerability at an early stage.In recent years,molecular imaging combined with nanoprobe technology has enabled precise visualization at the cellular and molecular levels by targeting pathological features of plaques(e.g.,lipid core,inflammation,thin fibrous cap,etc.).This article reviews the pathological features of VASPs,the limitations of existing imaging techniques,and the design principles and application progress of molecular imaging probes and discusses the challenges and future directions for their clinical translation.
