A diffusion tensor imaging study in middle-aged female patients with first-episode major depressive disorder
10.3760/cma.j.issn.1006-7884.2014.06.002
- VernacularTitle:抑郁症首次发病中年女性患者的弥散张量成像研究
- Author:
Junjie REN
1
;
Haiman BIAN
;
Gongying LI
;
Mengyuan YAO
;
Shengli CHEN
;
Shengzhang JI
Author Information
1. 300140,天津市第四中心医院放射科
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
White matter;
Magnetic resonance imaging;
Tract-based spatial statistic
- From:
Chinese Journal of Psychiatry
2014;47(6):326-330
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the microstructural abnormalities of white matter in middle-aged female patients with first-episode major depressive disorder by tract-based spatial statistics (TBSS).Methods Diffusion tensor imaging(DTI) was performed in 20 patients with major depressive disorder and 15 healthy controls matched for age,gender,and education.Fractional anisotropy (FA) values were compared between the patients and controls by TBSS.Results Compared with normal controls,FA values were significantly decreased in the white matter of the left prefrontal cortex,left internal capsule and the right precuneus (P ＜ 0.005,cluster ＞ 40).Conclusion The microstructural abnormalities of white matter integrity may occur early in the course of depression,the abnormal brain areas include the prefrontal-subcortical neural circuit and default mode network which are related to cognitive and emotional adjustment.
