Amplitude of low frequency fluctuation in female depression patients: a resting-state functional magnetic resonance imaging study
10.3760/cma.j.issn.1006-7884.2014.04.002
- VernacularTitle:女性抑郁症患者脑区静息态功能磁共振低频振幅特征及与症状严重程度的相关性
- Author:
Rui YAN
1
;
Zhijian YAO
;
Maobin WEI
;
Hao TANG
;
Qing LU
Author Information
1. 210029,南京医科大学附属脑科医院抑郁症专科
- Publication Type:Journal Article
- Keywords:
Depression;
Magnetic resonance imaging;
Amplitude of low frequency fluctuation
- From:
Chinese Journal of Psychiatry
2014;47(4):195-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore energy feature of the spontaneous neural activity in young female depressive patients,and its correlation to the severity of depressive symptoms.Methods Fourteen female depressive patients and 18 healthy controls were scanned with 3.0 T MRI scanner.The difference with amplitude of low frequency fluctuation (ALFF) between both groups was compared with the t-test,and the correlation analysis between ALFF of brain regions with significant difference and the severity of depressive symptoms was conducted.Results Compared with healthy group,the depression group showed significantly increased ALFF in the right cerebellum anterior lobe (Montreal Neurological Institute(MNI) coordinates (x,y,z):39,-54,-36; k =20; t=3.678,P ＜ 0.05),and decreased ALFF in the left posterior cingulate (MNI coordinates (x,y,z):-6,-45,15; k =18) and the left superior parietal lobule (MNI coordinates (x,y,z):-21,-78,48; k =20;t =-3.967,-3.669; both P ＜0.05; corrected by Alphasim).The ALFF in the right cerebellum anterior lobe was positively correlated to the number of depressive episodes (r=0.607,P =0.021),and negatively correlated to the HAMD17 total score and cognitive disturbance score (r =-0.595,P =0.025 ; r =-0.542,P =0.045,respectively).Conclusion Abnormal brain activity could emerge in female depressive patients during resting-state,the level of ALFF may be associated with severity of depressive symptoms and cognitive disturbance.
