Study on the Clinical and Mechanism of Stomach Disease Involving Intestine in Chronic Atrophic Gastritis from the Correlation of"Qi-Bacteria-Symptom"
10.19879/j.cnki.1005-5304.202504454
- VernacularTitle:从"气-菌-症"关联探讨慢性萎缩性胃炎胃病及肠的临床与机制研究
- Author:
Mengting ZHANG
1
;
Suhua XU
;
Yan XIONG
;
Yimeng CHEN
;
Yanfeng SHAO
;
Shanshan DING
;
Long ZHU
;
Xuejuan LIN
Author Information
1. 福建中医药大学中医学院,福建 福州 350122
- Publication Type:Journal Article
- Keywords:
chronic atrophic gastritis;
degree of qi-stagnation;
intestinal symptoms;
correlation analysis;
intestinal flora
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(11):149-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective Chronic atrophic gastritis(CAG)is often accompanied by intestinal flora disorder and intestinal symptoms,forming the phenomenon of"stomach disease involving intestine".This study explored the dynamic correlation between intestinal symptoms and qi-stagnation degree in patients with CAG qi-stagnation syndrome and analyzed the characteristics of gut microbiota from the perspective of"spleen-stomach system serving as the pivotal hub of qi movement"in TCM.Methods According to the syndrome element differentiation method,410 patients with CAG were divided into four groups:non-qi-stagnation group,mild qi-stagnation group,moderate qi-stagnation group and severe qi-stagnation group.Correlation analysis and 16S intestinal flora sequencing technology were used to analyze the correlation and differential flora between the degree of CAG qi-stagnation and intestinal symptoms.Results Patients with CAG qi-stagnation syndrome were often accompanied by intestinal symptoms such as frequent flatulence,poor defecation and alternating loose-constipated stools.The frequency of cases was significantly positively correlated with the degree of qi-stagnation"non-mild-moderate-severe"(P<0.05).There was a difference in the abundance of gut microbiota between the four groups of CAG qi-stagnation none,mild,moderate and severe.The relative abundance of Streptococcus,Subdoligranulum,Eubacterium_coprostanoligenes_group and Haemophilus was positively correlated with the degree of qi-stagnation.The relative abundance of Ruminococcus_torques_group and Butyricicoccus showed a negative correlation,and Haemophilus was statistically significant among the four groups(P<0.05).Conclusion This study can provide clinical evidence and micro-mechanism for the connotation of"gastrointestinal co-morbidities"and"different diseases with the same syndrome",which may open up new ideas for clinical diagnosis and treatment.
