Effects of olanzapine treatment upon liver fat content in first-episode schizophrenia patients: a preliminary study
10.3760/cma.j.issn.1006-7884.2014.04.010
- VernacularTitle:奥氮平对首次发病精神分裂症患者肝脏脂肪含量的影响
- Author:
Fangbin CHEN
1
;
Qi CHEN
;
Yuanyuan PAN
;
Jian SUN
;
Leping XU
;
Huanlin WANG
Author Information
1. 江苏大学
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Magnetic resonance spectroscopy;
Olanzapine;
Lipid metabolism
- From:
Chinese Journal of Psychiatry
2014;47(4):237-241
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of olanzapine treatment upon liver tat content (LFC)in first-episode schizophrenia patients.Methods A total of 25 first-episode schizophrenia patients were administered olanzapine alone with dosage ranging from 10 to 20 mg per day for eight weeks.1H-magnetic resonance spectroscopy (1H-MRS) was used for LFC measurements before and after eight-week olanzapine treatment.The results were compared with those of the normal control group (n =25).Other indicators,including body mass index (BMI),waist-height ratio (WHR),fasting plasma glucose (FPG),triglyceride (TG),total cholesterol (TC) and homeostasis model assessment of insulin resistance (HOMA-IR),were also assessed in the patients group.Results After olanzapine treatment,the LFC significantly increased against the pre-treatment level ((4.99 ± 1.79) ％ vs.(3.98 ± 0.83) ％,t =2.958,P ＜ 0.01),and against that of the normal control group ((4.99 ± 1.79)％ vs.(4.02 ± 0.80)％,t =2.436,P＜0.05).The levels of BMI,WHR,TG,TC and HOMA-IR were all significantly elevated after treatment.Before treatment,LFC was positively correlated to HOMA-IR,BMI,WHR and TG (r =0.447,0.424,0.421,0.413 ; all P ＜ 0.05),while after treatment,LFC was positively correlated to HOMA-IR and TG(r =0.425,0.400; both P ＜0.05) ; the increase of LFC between pre-and post-treatment was positively correlated to the increases of HOMA-IR and WHR (r =0.478,P ＜ 0.01 ; r =0.430,P ＜ 0.05).After treatment,the LFC of 4 patients (16％) surpassed the threshold diagnostic value of fatty liver (LFC ＞ 5.5％).Conclusion Olanzapine treatment would significantly elevate liver fat deposition in first-episode schizophrenia patients.
