Analysis of cerebral hemodynamics in uremic patients complicated with depressive symptoms using transcranial color-coded Doppler
10.16753/j.cnki.1008-2344.2025.02.011
- VernacularTitle:经颅彩色多普勒超声对尿毒症合并抑郁症状患者脑血流动力学的研究
- Author:
Yuhang LI
1
;
Meng ZHANG
1
;
Qihui YANG
1
;
Na ZHANG
1
Author Information
1. 沈阳医学院附属中心医院电诊科,辽宁 沈阳 110024
- Publication Type:Journal Article
- Keywords:
transcranial color-coded Doppler;
uremia;
depressive symptoms;
cerebral blood flow
- From:
Journal of Shenyang Medical College
2025;27(2):174-179,224
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the cerebral hemodynamic characteristics of uremic patients complicated with depressive symptoms by transcranial color-coded Doppler(TCCD),and explore the correlation between cerebral hemodynamic indicators and uremia complicated with depressive symptoms.Methods:A total of 70 uremic patients received hemodialysis in our hospital from Dec 2022 to Dec 2023 were enrolled,in which 37 patients complicated with depressive symptoms were selected as the research group,and 40 patients without depressive symptoms were selected as the control group.Peak systolic velocity(PSV),end diastolic velocity(EDV),mean velocity(MV),and pulsatility index(PI)of bilateral middle cerebral artery(MCA)were compared.Binary logistic regression was used to analyze risk factors for uremia complicated with depressive symptoms,and receiver operating characteristic(ROC)curves were generated for key parameters.Results:There was no significant difference in PSV between the two groups(P＞0.05),while EDV and MV of bilateral MCA in the research group were lower but PI was higher than those in the control group(P＜0.05).Age was positively correlated with the depressive symptoms in uremic patients,while EDV,MV of bilateral MCA and left PSV were negatively correlated with depressive symptoms of uremic patients(P＜0.05).The elevated level of HCO3-in blood increased the risk of uremia complicated with depressive symptoms(OR=1.245,95%CI:1.024-1.513).When the left EDV was 41.25 cm/s,the predicted occurrence rate of depressive symptoms in uremic patients was 74.6%,with a specificity of 62%and a sensitivity of 85%.Conclusions:EDV and MV of bilateral MCA in patients with uremia complicated with depressive symptoms were lower than those in patients with uremia without depressive symptoms.Age,EDV and MV of bilateral MCA and PSV of left MCA were associated with depressive symptoms.Left EDV＜41.25 cm/s may serve as a hemodynamic marker for early clinical detection of depressive symptoms in uremia.TCCD can provide a reference for early clinical detection of uremic patients complicated with depressive symptoms.
