Analysis of Predictive Factors for the Efficacy of Traditional Chinese Medicine in Treating Myasthenia Gravis and Development and Validation of the Nomogram Model
10.11842/wst.20240330001
- VernacularTitle:中医药治疗重症肌无力的疗效预测因素分析及列线图的构建与验证
- Author:
Ke WANG
1
;
Xinchen JI
;
Ying ZHANG
;
Jing LU
;
Baitong WANG
;
Dongmei ZHANG
;
Peng XU
;
Jian WANG
Author Information
1. 长春中医药大学中医学院 长春 130117
- Publication Type:Journal Article
- Keywords:
Myasthenia gravis;
Traditional Chinese medicine;
Jianpi Yiqi Busui Formula;
Efficacy prediction;
Nomogram
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2025;27(3):674-682
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relevant factors affecting the efficacy of traditional Chinese medicine in treating MG,and to develop and validate a nomogram model,in order to personalize the prediction of the probability of benefits for MG patients after traditional Chinese medicine treatment,further guide clinical physicians in targeted medication,and provide guidance for the traditional Chinese medicine treatment of MG.Method Retrospective analysis of MG patients who visited the Affiliated Hospital of Changchun University of Traditional Chinese Medicine from March 2018 to June 2022,13 clinical factors were selected to evaluate the results.To acquire independent factors,univariate and multivariate Logistic analyses were performed.The area under the receiver operating characteristic curve,Harrell's concordance index,calibration curve,and decision curve analyses were used to evaluate the predictive ability,accuracy,and clinical practicability of the prediction model.Results A total of 204 cases were included,divided into derivation cohort 139 cases and temporal validation cohort 65 cases.Multivariate Logistic regression showed 4 independent predictors affecting effectiveness of traditional Chinese medicine in treating MG,including age at onset,repetitive nerve stimulation positive,oral immunosuppressant and anxiety/depression.AUC values for the model group and validation group were 0.76(95%CI:0.68-0.84)and 0.83(95%CI:0.71-0.95),respectively,and based on calibration curve and decision curve analysis,we concluded that the nomogram showed excellent performance.Conclusion MG patients may experience a decrease in short-term efficacy with age,positive RNS,concomitant emotional abnormalities,or recent history of immunosuppressive therapy.This nomogram effectively predicts the possibility of short-term effective traditional Chinese medicine treatment in MG patients.
