Association between the initiative-aggressive behaviors and the short tandem repeats loci Penta D and Penta E
10.3760/cma.j.issn.1006-7884.2014.01.010
- VernacularTitle:短串联重复序列基因座Penta D和Penta E与主动攻击行为的关联研究
- Author:
Chun YANG
1
;
Huajie BA
;
Haiying YU
;
Hanqing ZHAO
;
Wei GUO
;
Zhiqin GAO
Author Information
1. 解放军第一○二医精院神科,常州,213003
- Publication Type:Journal Article
- Keywords:
Personality disorders;
Microsatellites repeats;
Polymorphism,genetic;
Case-control studies
- From:
Chinese Journal of Psychiatry
2014;47(1):39-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of the initiative-aggressive behaviors and short tandem repeats (STRs) loci Penta D and Penta E.Methods The biological samples of 307 initiativeaggressive violent offenders and 459 healthy persons without violent behavior were collected.Then all of the sample were amplified by PowerPlex(R) 16 HS System and separated by electrophoresis to compare the genotypes and alleles frequency of Penta D and Penta E in both groups.Results Penta D and Penta E loci in both groups were found to coincide with Hardy-Weinberg equilibrium(P ＞0.05).There were significant difference of alleles and genotypes frequency at loci Penta D and Penta E between both groups (alleles:P =0.000 0,P =0.001 3; genotypes:P =0.001 2; P =0.000 0).Univarite analysis showed significant differences at allelle 5,6 on Penta D and allelle 9 on Penta E between both groups (P =0.002 4,P =0.001 6,P =0.002 1),with the OR values being 0.113 (95％ CI:0.015-0.869),12.092 (95 ％ CI:1.506-96.924),0.225 (95％ CI:0.078-0.648),respectively.Conclusion Penta D and Penta E might be associated with initiative-aggressive behavior,with allelle 6 on Penta D being the susceptible factor and allelle 5 on Penta D and allelle 9 on Penta E might being the protective factors.
