P300 components of auditory event-related potentials in first episode deficit and non-deficit schizophrenia
10.3760/cma.j.issn.1006-7884.2014.01.006
- VernacularTitle:缺陷型及非缺陷型精神分裂症首次发病患者听觉事件相关电位P300的比较研究
- Author:
Zhe LI
1
;
Wei DENG
;
Yuanyuan HAN
;
Yinfei LI
;
Xiang LIU
;
Zhong ZHENG
;
Tao LI
Author Information
1. 四川大学华西医院心理卫生中心,成都,610041
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Event-related potentials,P300;
Deficit;
Non-deficit
- From:
Chinese Journal of Psychiatry
2014;47(1):21-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the P300 components of auditory event-related potentials in first episode deficit and non-deficit schizophrenia and the relationship between P300 and clinical variables.Methods P300 components of event-related potentials were measured in 50 patients with non-deficit schizophrenia (NDS),40 patients with deficit schizophrenia (DS) and 50 unrelated healthy controls (HC).The mental status of patients with schizophrenia was determined using the Positive and Negative Syndrome Scale (PANSS).The global functioning status was assessed using the Global Assessment of Functioning Scale (GAF).Partial correlations were computed to explore associations among the P300 and the clinical data when controlling for gender,age and education level in NDS and DS.Results Compared to HC group,both groups of NDS and DS showed significantly delayed N1 [HC (100.0 ± 14.3) ms,NDS (115.5 ± 29.1)ms,DS (115.0±15.1) ms],P2[HC(167.2 ±14.3)ms,NDS (184.7 ±39.6) ms,DS (186.0±25.0) ms] and N2 [HC (214.3 ± 18.4) ms,NDS (242.8 ± 44.9) ms,DS (240.3 ± 33.7) ms] latency (F =8.476,6.493,10.449,respectively,P ＜ 0.05),significantly reduced N1 [HC (10.7 ± 4.6) uV,NDS (6.9 ± 5.9) uV,DS (7.2±2.7)uV] and N2[HC(7.6±5.8) uV,NDS(3.7±6.2) uV,DS (1.9±6.4) uV] amplitude (F =8.610,11.651,respectively,P ＜ 0.05),as well as significantly delayed button mean reaction time [HC (357.4 ± 50.2) ms,NDS (508.6 ± 139.1) ms,DS (546.7 ± 482.4) ms] (F =6.349,P ＜ 0.05).While compared to HC group,only NDS group showed significantly delayed latency of P3b (P ＜ 0.05),whereas,only DS group showed significantly delayed latency of P3a (P ＜ 0.05).No correlation was found between P3b latency and clinical variables (course,age at onset,GAF score,PANSS total score,PANSS positive symptoms,PANSS negative symptoms and PANSS general psychopathology) in NDS (r =0.195,-0.195,-0.121,0.078,0.236,-0.138,0.062,all P ＞ 0.05),whereas no correlation was found between P3a latency and the same clinical variables in DS (r =0.002,-0.133,-0.219,-0.014,-0.179,0.032,0.112,all P ＞ 0.05).Conclusions Generalized abnormalities of P300 may exist in deficit and non-deficit schizophrenia.P3a and P3b latency may represent the trait marker of deficit and non-deficit patients with schizophrenia respectively.
