The changes of integrity of long association fiber tracts and cognitive function in remitted geriatric depression patients: a follow-up study
10.3760/cma.j.issn.1006-7884.2014.01.004
- VernacularTitle:老年抑郁症恢复期患者白质长纤维束完整性与认知功能改变的随访研究
- Author:
Zhenghua HOU
1
;
Yonggui YUAN
;
Feng BAI
;
Gang HOU
Author Information
1. 241000,上海交通大学BIO-X中心附属芜湖市第四人民医院精神科
- Publication Type:Journal Article
- Keywords:
Aged;
Depressive disorder;
Convalescence;
Fiber tracts;
Cognition;
Follow-up studies
- From:
Chinese Journal of Psychiatry
2014;47(1):12-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was aimed to investigate the association between integrity of long association fiber tracts changes and neuropsychological performance in patients with remitted geriatric depression (RGD).Methods Using the Mini Mental State Examination (MMSE),Auditory Verbal Learning Test (AVLT),Symbol Digit Modality Test (SDMT),Trail Making Test-A&B (TMT-A&B),Digit Span Test (DST) to collect general clinical data and neuropsychological data.14 patients with RGD and 19 healthy volunteers as control were recruited in this follow-up study.Subjects were scanned using a General Electric 1.5 Tesla scanner to acquire diffusion tensor imaging (DTI) images.Using the DTI studio software to calculate the fraction anisotropy (FA) value of region of interesting (ROI) in 13 RGD patients and 19 controls.Results (1) At baseline,RGD patients showed significant poorer performance in some specific domain of cognitive function,such as AVLT,SDMT,TMT A&B and DST than controls [RGD patients:5.93±2.56,25.00 ± 15.04,133.50 ±96.66,237.71 ± 138.42,11.79 ±2.08; controls:8.16 ± 1.83,34.95 ± 8.89,69.58 ± 27.92,139.74 ± 38.11,13.16 ± 1.74.At follow-up,the score of MMSE,AVLT,DST in RGD patients showed some degrees of decline (27.79 ±3.97,5.00 ±2.83,11.71 ±2.13,SDMT,TMT-A&B exhibited increased score 27.07 ± 15.78,70.43 ±25.52,157.71 ±36.92,but only the change of TMT-A and B was statistically significant (P =0.038,0.032).After follow-up,the RGD patients exhibited lower scores of DST than controls [(11.71 ±2.13) vs.(14.05 ±2.72),P ＜0.01].(2) At baseline,the FA value of left cingulate fasciculus (posterior) in RGD patients was lower than controls [(0.50 ± 0.08) vs.(0.57 ±0.05),P =0.015].At follow-up,the FA value of right frontooccipital fasciculus in RGD patients was lower compared to controls [(0.50 ± 0.03) vs.(0.54 ± 0.06),P =0.025],the FA value of corpus callosum (splenium) was decreased significantly in RGD patients [(0.83 ± 0.05) vs.(0.77 ± 0.06),P =0.013].In controls,the FA value of left cingulate fasciculus (middle) exhibited significant decrease [(0.60 ± 0.06) vs.(0.54 ± 0.06),P =0.011].(3) Correlation analysis showed that the decreased FA value of splenium of corpus callosum was negatively related to the increase of SDMT score (r =-0.617,P =0.025).Conclusions The findings suggest that the regional fiber connection change be closely related to cognitive impairment.The abnormality of integrity long white matter fiber bundle might be associated with impaired cognitive function in patients with RGD.
