Analysis of Medication Patterns for the Treatment of Rheumatoid Arthritis by Using National Patented Traditional Chinese Medicine Formulas
10.16466/j.issn1005-5509.2025.05.019
- VernacularTitle:基于国家专利的中药复方治疗类风湿性关节炎用药规律分析
- Author:
Zihan HUANG
1
;
Hejing PAN
;
Liaoyao WANG
Author Information
1. 浙江中医药大学 杭州 310053
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
medication patterns;
traditional Chinese medicine compound formula;
data mining;
staged treatment;
national patent;
different treatments for the same disease;
syndrome
- From:
Journal of Zhejiang Chinese Medical University
2025;49(5):649-655
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To explore data on traditional Chinese medicine formulas for the treatment of rheumatoid arthritis(RA),analyze medication patterns and provide ideas for the clinical staging treatment of RA.[Methods]Using the China Patent Publication Platform of the State Intellectual Property Office,the patent data of traditional Chinese medicine compounds for RA published from the establishment date of the database to November 2023 were systematically collected,and the frequency of drug application,nature and taste,and efficacy of the included traditional Chinese medicine formulas were analyzed.Correlation analysis,cluster analysis and latent structure analysis were used to explore the core prescriptions of traditional Chinese medicine in the treatment of different stages of RA.[Results]Two hundred and ninety-nine traditional Chinese medicine formulas were included,including 537 traditional Chinese medicines,with a total frequency of 3 739 times.The nature and flavor of the medicines are primarily categorized as warm,neutral,and cold.The channel tropism of the medicines is generally classified into the liver,spleen,kidney,and heart meridians.High-frequency traditional Chinese medicine can be classified into six primary categories and nine secondary subcategories.The high-frequency drug combinations used in association analysis included"Huangqi → Guizhi"and"Ruxiang → Myrrh".The cluster analysis of 58 high-frequency traditional Chinese medicines with frequency≥20 times was carried out,and the results showed that 6 clusters were formed.Among them,wind and dampness obstruction and deficiency of Qi and blood belonged to the pre-RA state,damp-heat obstruction belonged to the acute phase,cold dampness obstruction belonged to the chronic phase,phlegm stasis obstruction and liver and kidney deficiency belonged to the remission phase.[Conclusion]Traditional Chinese medicine formulas therapy for RA often starts from the three major causes of deficiency,evil and blood stasis,by using drugs that dispel wind and dampness,promote blood circulation and remove blood stasis,and nourish deficiency.It follows the principle of"treating the same disease differently"and emphasizes staged treatment,Which providing a certain reference for clinical treatment.
