Clinical effect of meropenem combined with cefotaxime sodium on treatment of interstitial pneumonia patients complicated with pulmonary infection
10.11816/cn.ni.2025-240914
- VernacularTitle:美罗培南联合头孢噻肟钠治疗间质性肺炎并发肺部感染的疗效
- Author:
Yan CHEN
1
;
Xueying CHEN
;
Liqiu YANG
;
Ying DAI
;
Guohui YANG
Author Information
1. 贵州医科大学临床学院,贵州贵阳 550000;贵阳市第二人民医院呼吸与危重症医学科,贵州贵阳 550000
- Publication Type:Journal Article
- Keywords:
Meropenem;
Cefotaxime sodium;
Interstitial pneumonia;
Pulmonary infection;
Vascular endothelial growth factor;
Toll-like receptor 2;
Transforming growth factor β1
- From:
Chinese Journal of Nosocomiology
2025;35(9):1305-1310
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the clinical effect of meropenem combined with cefotaxime sodium on treatment of interstitial pneumonia(IP)patients complicated with pulmonary infection and observe the influence on vascular endothelial growth factor(VEGF),Toll-like receptor 2(TLR2)and transforming growth factor β1(TGF-β1)so as to provide guidance for treatment of the IP patients complicated with pulmonary infection and assessment of curative effect.METHODS A total of 102 IP patients complicated with pulmonary infection who were treated in Guiyang Second People's Hospital from Feb,2022 to Feb,2024 were recruited as the research subjects and were randomly divided into the CTX group and the combination group,with 51 cases in each group.The CTX group was treated with cefotaxime sodium,and the combination group was given meropenem combined with cefotaxime sodium.The curative effect,lung function indexes,blood gas indexes,T lymphocyte subsets,peripheral blood VEGF,TLR2 and TGF-β1 were observed and compared between the two groups.RESULTS There was significant difference in the effective rate of treatment between the combination group and the CTX group(Z=7.229,P=0.007).The lung function of the combination group was better than that of the CTX group after the treatment for 7 days(P＜0.05);the levels of helper T cell type 1(Th1),Th1/Th2 and CD4+Foxp3+Treg of the combination group were higher than those of the CTX group(P＜0.05),while the Th2 level of the combination group was low-er than that of the CTX group(P＜0.05).The levels of VEGF,TLR2 mRNA and TGF-β1 of the combination group were respectively(32.14±8.77)pg/ml,(1.23±0.30)mRNA and(17.25±4.56)pg/ml,lower than those of the CTX group(P＜0.05).There were no significant differences in the drug-induced adverse reactions between the two groups of patients.CONCLUSIONS Meropenem combined with cefotaxime sodium can boost the curative effect on IP patients complicated with pulmonary infection,improve the lung function and blood gas indexes,reg-ulate the immune response,intensify the immune function,reduce the expression levels of VEGF,TLR2 mRNA and TGF-β1,and promote the rehabilitation of the patients.
